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Identification of Bichalcones as Sirtuin Inhibitors by Virtual Screening and In Vitro Testing.

Identification of Bichalcones as Sirtuin Inhibitors by Virtual Screening and In Vitro Testing.
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Karaman B, Alhalabi Z, Swyter S, Mihigo SO, Andrae-Marobela K, Jung M, Sippl W, Ntie-Kang F,


Karaman B, Alhalabi Z, Swyter S, Mihigo SO, Andrae-Marobela K, Jung M, Sippl W, Ntie-Kang F, (click to view)

Karaman B, Alhalabi Z, Swyter S, Mihigo SO, Andrae-Marobela K, Jung M, Sippl W, Ntie-Kang F,

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Molecules (Basel, Switzerland) 2018 02 1423(2) pii 10.3390/molecules23020416

Abstract

Sirtuins are nicotinamide adenine dinucleotide (NAD⁺)-dependent class III histone deacetylases, which have been linked to the pathogenesis of numerous diseases, including HIV, metabolic disorders, neurodegeneration and cancer. Docking of the virtual pan-African natural products library (p-ANAPL), followed by in vitro testing, resulted in the identification of two inhibitors of sirtuin 1, 2 and 3 (sirt1-3). Two bichalcones, known as rhuschalcone IV () and an analogue of rhuschalcone I (), previously isolated from the medicinal plant, were shown to be active in the in vitro assay. The rhuschalcone I analogue () showed the best activity against sirt1, with an ICvalue of 40.8 µM. Based on the docking experiments, suggestions for improving the biological activities of the newly identified hit compounds have been provided.

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