Anaplastic gliomas (AGs) are a type of primary brain tumour that is exceedingly diverse. Isocitrate dehydrogenase (IDH) mutation status has recently been discovered to be the most critical characteristic in predicting survival. The major goal of this study was to find prognostic markers other than IDH status that could influence survival. Gross-total resection, near-total recovery, subtotal resection, and partial resection were used to characterise the amount of resection (EOR). A neurological examination and MRI were used to assess the clinical result one month after treatment and every four months thereafter. The Response Assessment in Neuro-Oncology working group determined how tumour progression was measured.
The current study included 142 individuals out of 402 who were referred to the authors’ institution for AG. With a median age of 43 years (range 19–70 years), eighty-eight percent (62%) were male and 54 percent (38%) were female. The majority of them (67.6%) had mutant IDH tumours and methylated O 6-methylguanine-DNA-methyltransferase (MGMT) promoter status (71.8 percent ) The more effective treatment was sequential radio-chemotherapy. EOR and RTV, in addition to IDH status, have been shown to have a statistical impact on survival. Adjuvant radiation has been shown to play a critical role in all AG patients, regardless of tumour characteristics.
Reference Link – https://thejns.org/view/journals/j-neurosurg/135/1/article-p64.xml