The purpose of this study was to analyze the sensitization profile in a representative sample of the population and to relate patterns of allergens and allergen components to allergic symptoms.
195 adolescents in total took part in this clinical study, which included a self-reported questionnaire and in vitro IgE testing.
Sensitization to airborne allergens was more common than sensitization to food allergens. IgE response was significantly higher in airborne allergens among adolescents with rhinitis and eczema. Among 53 children with allergic symptoms according to the questionnaire, 60% were sensitized. Sensitization to food allergens was found among those with rhinitis, but only to PR-10 proteins. None of the participants had IgE to seed storage proteins.
The adolescents in this study were mainly sensitized to grass pollen and rarely to specific food allergens. The major grass pollen allergen Phl p 1 was the main sensitizer, followed by Cyn d 1 and Phl p 2. 61 percent reporting any allergic symptoms were sensitized and the allergen components associated with wheeze and rhinoconjunctivitis were Fel d 4, Der f 2, and Can f 5.
Reference: https://clinicalmolecularallergy.biomedcentral.com/articles/10.1186/s12948-019-0110-6
