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Immunity Following Childhood Vaccinations in Perinatally HIV-Exposed Children with and without HIV Infection in Latin America.

Immunity Following Childhood Vaccinations in Perinatally HIV-Exposed Children with and without HIV Infection in Latin America.
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Succi RC, Krauss MR, Harris DR, Machado DM, de Moraes-Pinto MI, Mussi-Pinhata MM, Pavia Ruz N, Pierre RB, Kolevic Roca LA, Joao E, Foradori I, Scotta MC, Hazra R, Siberry GK, ,


Succi RC, Krauss MR, Harris DR, Machado DM, de Moraes-Pinto MI, Mussi-Pinhata MM, Pavia Ruz N, Pierre RB, Kolevic Roca LA, Joao E, Foradori I, Scotta MC, Hazra R, Siberry GK, , (click to view)

Succi RC, Krauss MR, Harris DR, Machado DM, de Moraes-Pinto MI, Mussi-Pinhata MM, Pavia Ruz N, Pierre RB, Kolevic Roca LA, Joao E, Foradori I, Scotta MC, Hazra R, Siberry GK, ,

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The Pediatric infectious disease journal 2017 11 14() doi 10.1097/INF.0000000000001831

Abstract
BACKGROUND
Perinatally HIV-infected (PHIV) children are at risk for undervaccination and poor vaccine response at four years of age. Childhood vaccine coverage and immune response were compared between PHIV and HIV-exposed uninfected (HEU) children in Latin America and the Caribbean.

METHODS
PHIV and HEU children were enrolled prospectively at fifteen sites from 2002-2009. Full vaccination by age four years was defined as: three hepatitis B virus (HBV) vaccine doses; four tetanus toxoid-containing vaccine doses; three doses of Haemophilus influenzae type b (Hib) vaccine by age 12 months or ≥1 dose given after age 12 months; one measles-containing vaccine dose; one rubella-containing vaccine dose. Immunity was defined by serum antibody titer. Fisher’s exact test (for categorical measures) and t-test (for continuous measures) were used for comparisons.

RESULTS
Among 519 children seen at age four years, 191 had serum specimens available (137 PHIV, 54 HEU). Among those with specimens available, 29.3% initiated combination antiretroviral therapy (cART) <12 months of age, 30.9% initiated at ≥12 months of age, and 39.8% had not received cART by the time they were seen at four years of age.At four years of age, 59.9% were on PI-containing cART (cART/PI), and 20.4% were on no ARV. PHIV children were less likely than HEU children to be fully vaccinated for tetanus (55.5% vs. 77.8%, p=0.005) and measles and rubella (both 70.1% vs. 94.4%, p<0.001). Among those fully vaccinated, immunity was significantly lower among PHIV than HEU for all vaccines examined: 20.9% vs. 37.8% for HBV (p=0.04), 72.0% vs. 90.5% for tetanus (p=0.02), 51.4% vs. 68.8% for Hib (p=0.05), 80.2% vs. 100% for measles (p<0.001) and 72.9% vs. 98.0% for rubella (p<0.001) vaccine, respectively. CONCLUSIONS
Compared to HEU, PHIV children were significantly less likely to be immune to vaccine-preventable diseases when fully vaccinated. Strategies to increase immunity against vaccine-preventable diseases among PHIV require further study.

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