[Immunization strategy of hepatitis B vaccine among adults in China: evidence based-medicine and consideration].

Author Information (click to view)

Xu AQ, Zhang L,

Xu AQ, Zhang L, (click to view)

Xu AQ, Zhang L,


Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 50(6) 473-7 doi 10.3760/cma.j.issn.0253-9624.2016.06.001


With the effective control of hepatitis B infection among children, the adults especial the young ones become the main population for new hepatitis B virus infection. Now the adults receive hepatitis B vaccination voluntarily and at their own expense in China and the coverage is low. The high immunogenicity of hepatitis B vaccine has been proven among healthy adults. Although the safety of hepatitis B vaccination has been documented among high-risk population such as HIV-infected people, injecting drug users and patients with chronic hepatitis disease, their antibody seroconversion rate after hepatitis B vaccination is lower than the healthy adults. Hepatitis B vaccination is recommended to population at high risk officially in many countries and some effects have been achieved. It is urgent to improve the strategy of hepatitis B vaccination among adults to fasten the control of hepatitis B in China, along with the researches about the long-term efficacy of hepatitis B vaccine among adults, the immunogenicity of hepatitis B vaccination among high-risk adults and the economical evaluation about different adult immunization strategy of hepatitis B.

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