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Impact of long-term antiretroviral therapy interruption and resumption on viral reservoir in HIV-1 infected patients.

Impact of long-term antiretroviral therapy interruption and resumption on viral reservoir in HIV-1 infected patients.
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Montserrat M, Plana M, Guardo AC, Andrés C, Climent N, Gallart T, Leal L, Gatell JM, Sánchez-Palomino S, García F,


Montserrat M, Plana M, Guardo AC, Andrés C, Climent N, Gallart T, Leal L, Gatell JM, Sánchez-Palomino S, García F, (click to view)

Montserrat M, Plana M, Guardo AC, Andrés C, Climent N, Gallart T, Leal L, Gatell JM, Sánchez-Palomino S, García F,

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AIDS (London, England) 31(13) 1895-1897 doi 10.1097/QAD.0000000000001560

Abstract

: We assessed if the increase on viral reservoir after long-term antiretroviral therapy (ART) interruption (ATI) is reversible upon ART resumption in chronic HIV-1 infected patients. Total HIV-1 DNA increased to pre-ART levels after 48 weeks of ATI to return to pre-ATI levels after 104 weeks of ART resumption. Conversely, integrated HIV-1 DNA remained elevated after ART reinitiation. These data suggest that the increase in reservoir after long-term ART discontinuation might not be reversible at midterm.

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