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Impact of Obesity on a Chinese Population with Erosive Esophagitis and Barrett’s Esophagus.

Impact of Obesity on a Chinese Population with Erosive Esophagitis and Barrett’s Esophagus.
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Lee SW, Lien HC, Lee TY, Tung CF, Yeh HZ, Chang CS,


Lee SW, Lien HC, Lee TY, Tung CF, Yeh HZ, Chang CS, (click to view)

Lee SW, Lien HC, Lee TY, Tung CF, Yeh HZ, Chang CS,

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Gut and liver 2016 12 16() doi 10.5009/gnl16211
Abstract
Background/Aims
The aim of this study was to investigate the associations between obesity and erosive esophagitis (EE) or Barrett’s esophagus (BE) in a Chinese population.

Methods
Data from subjects were retrospectively collected from 2006 to 2009. Individuals with BE were identified and age- and sex-matched at a 1:2 ratio with normal esophagocardial junction and EE patients. The subjects were stratified into two groups: the normal weight group and overweight/ obesity group (body mass index ≥25 mg/m(2)) or the normal waist group and abdominal obesity group (waist circumference ≥90 cm for men and ≥80 cm for women).

Results
Overall, 45%, 72%, and 52% were overweight/obese and 23%, 65%, and 18% had abdominal obesity in the normal, EE, and BE groups, respectively. Positive associations were identified between EE and overweight/obesity (odds ratio [OR], 3.14; 95% confidence interval [CI], 1.75 to 5.66) and abdominal obesity (OR, 6.22; 95% CI, 3.34 to 11.57); however, the associations were nonsignificant between BE and overweight/obesity (OR, 1.32; 95% CI, 0.67 to 2.61) or abdominal obesity (OR, 0.73; 95% CI, 0.31 to 1.73). Female BE patients had a significantly increased rate of being overweight/ obese.

Conclusions
Obesity is a contributing factor in EE. The association of BE and obesity was not significant, with the exception of female BE cases.

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