LVH is associated with augmented risk for mortality in patients with CAD. These patients often have OSA. We aimed to evaluate the relationship between OSA and the LVMI in men with CAD.
Consecutive patients with CAD were recruited and underwent overnight portable monitoring for the assessment of OSA. LVMI was ascertained using high-resolution echocardiography. Univariate and multivariate regression analyses were conducted to explore the associations between the OSA parameters and the LVMI levels.
1,053 examined male patients with CAD were taken as sample for the study, 425 had moderate-to-severe OSA. The prevalence of LVH was 36.0%. The mean LVMI values increased with increasing OSA severity. Patients with respiratory event index had 2.30 times increased risk of LVH than those without OSA independent of confounders. The minimum oxygen saturation levels were the strongest factor correlated with LVMI of several OSA indices. Patients with minimum oxygen saturation < 70% had an adjusted odds ratio of 3.62 for LVH development compared with those with minimum oxygen saturation ≥ 90%.
The study concluded that OSA severity was associated with a higher likelihood of LVH in men with CAD, which is partially related to severe nocturnal intermittent hypoxemia. Aggressive effort at managing OSA among patients with CAD may further reduce the cardiovascular risk.