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Impact of time-related factors on biologically accurate radiotherapy treatment planning.

Impact of time-related factors on biologically accurate radiotherapy treatment planning.
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Wakisaka Y, Yagi M, Sumida I, Takashina M, Ogawa K, Koizumi M,


Wakisaka Y, Yagi M, Sumida I, Takashina M, Ogawa K, Koizumi M, (click to view)

Wakisaka Y, Yagi M, Sumida I, Takashina M, Ogawa K, Koizumi M,

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Radiation oncology (London, England) 2018 02 2313(1) 30 doi 10.1186/s13014-018-0973-6

Abstract
BACKGROUND
The incomplete repair (IR) model expresses the cell repair effect from radiation-induced damage over time, which is given little consideration in actual treatment planning. By incorporating the IR model into the normal tissue complication probability (NTCP), the accuracy and safety of treatment plan evaluations concerning the effect of repair can be improved. This study aims to evaluate the impact of incorporating the IR model into the NTCP by varying time-related factors such as the repair half-time (T) and the junction-shift sc3hedule in craniospinal irradiation (CSI).

METHODS
CSI was planned retrospectively, and the NTCP of the spinal cord was calculated with the IR model for values of Tfrom 1 to 10 h. The NTCP in the case of changing the junction-shift schedule was also examined in the same manner.

RESULTS
The NTCP with the IR model increased with increasing T, which is prominent for the larger T. By changing the junction-shift schedule, the NTCP with the IR model decreased when adjacent fields overlapped.

CONCLUSIONS
The IR model is a valuable addition to treatment planning because it enables the NTCP to be evaluated including the effect of repair and differences in scheduling to be reflected in the NTCP. However, these are largely dependent on the value of the T.

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