We compared the impacts of linear (LP) and non-linear (NLP) aerobic training periodizations on left ventricular (LV) function and geometry in coronary artery disease (CAD) patients.
39 CAD patients were randomized to either a 3-month isoenergetic supervised LP or NLP. All underwent standard echocardiography with assessment of 3D LV ejection fraction (LVEF), diastolic function, strain (global longitudinal [GLS], radial and circumferential strain), and strain rate at baseline and study end. Training was performed 3 times/week and included high-intensity interval and moderate-intensity continuous training sessions. Training load was progressively increased in the LP group, while it was deeply increased and intercepted with a recovery week each fourth week in the NLP group.
On the 34 analyzed patients, we found similar improvements for 3D LVEF (Effect Size [ES], LP: 0.29 and NLP: 0.77), radial strain (ES, LP: 0.58; NLP: 0.48, and radial strain rate (ES, LP: 0.87; NLP: 0.17) in both groups (time for all: p≤0.01). All other parameters of cardiac function remained similar.
NLP and LP leaded to similar improvements in 3D LVEF and radial strain suggesting a favorable positive cardiac remodeling through myofibers reorganization. These findings must be investigated in patients with more severe cardiac dysfunction. The study was registered on ClinicalTrials.gov (NCT03443193). Novelty: • Linear and non-linear periodization programs improved radial strain, accompanied by improvement of ejection fraction • Both aerobic periodization programs did not negatively impact cardiac function in coronary artery disease patients.