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Improvement of glycemic state among responders to Sofosbuvir – based treatment regimens: Single center experience.

Improvement of glycemic state among responders to Sofosbuvir – based treatment regimens: Single center experience.
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Abdel Alem S, Elsharkawy A, Fouad R, Adel E, Abdellatif Z, Musa S, Nagy A, Hussein MS, Yosry A, Esmat G,


Abdel Alem S, Elsharkawy A, Fouad R, Adel E, Abdellatif Z, Musa S, Nagy A, Hussein MS, Yosry A, Esmat G, (click to view)

Abdel Alem S, Elsharkawy A, Fouad R, Adel E, Abdellatif Z, Musa S, Nagy A, Hussein MS, Yosry A, Esmat G,

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Journal of medical virology 2017 07 08() doi 10.1002/jmv.24897
Abstract
BACKGROUND
Chronic HCV infection has emerged as a complex multifaceted disease with manifestations extending beyond the liver. HCV plays a direct role in glucose metabolism leading to both insulin resistance and type 2 diabetes.

AIMS
To evaluate the changes in the glycemic state following Sofosbuvir-based treatment regimens in diabetic HCV patients.

METHODS
Four hundred chronic hepatitis C patients who underwent Sofosbuvir-based treatment regimens were retrospectively screened. Sixty-fivediabetic HCV patients only enrolled in our analysis. Baseline demographic and laboratory data were recorded. Pretreatment Transient elastography was performed. At 24-week post EOT (SVR24), Fasting Plasma glucose and Hemoglobin A1c were re-evaluated and compared with baseline.

RESULTS
All enrolled diabetic patients were responders. They showed statistically significant decline in Fasting Plasma glucose and Hemoglobin A1c values at SVR24. Whatever the degree of hepatic fibrosis, the level of Fasting Plasma glucose and Hemoglobin A1c decreased at SVR24 in comparison to baseline level. Fifty-one patients showed improvement in their Hemoglobin A1c values at SVR24 and this improvement was more likely to occur among patients with low Body mass index. The reduction in Fasting Plasma glucose >20 mg/dl (>1.1 mmol/L) and Hemoglobin A1c ≥0.5 % wasn’t associated with age, gender or hepatic fibrosis stage.

CONCLUSION
Sofosbuvir-based regimens are a highly efficient antiviral therapy for diabetic chronic HCV patients resulted in improvement in Fasting Plasma glucose and Hemoglobin A1c. This article is protected by copyright. All rights reserved.

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