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Improving bioassay sensitivity through immobilization of bio-probes onto reactive micelles.

Improving bioassay sensitivity through immobilization of bio-probes onto reactive micelles.
Author Information (click to view)

Jiménez-Sánchez G, Terrat C, Verrier B, Gigmes D, Trimaille T,


Jiménez-Sánchez G, Terrat C, Verrier B, Gigmes D, Trimaille T, (click to view)

Jiménez-Sánchez G, Terrat C, Verrier B, Gigmes D, Trimaille T,

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Chemical communications (Cambridge, England) 53(57) 8062-8065 doi 10.1039/c7cc02057k

Abstract

An antigen probe (HIV-1 p24) immobilized onto N-succinimidyl ester based micelles was used as a solid phase coating in ELISA test, and induced a significant improvement in antibody detection sensitivity as compared to the standard free antigen coating. The relevance of this straightforward approach to improve the bioassay sensitivity was confirmed by using biotin as a generic probe.

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