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In vitro cytotoxicity activity of novel Schiff base ligand-lanthanide complexes.

In vitro cytotoxicity activity of novel Schiff base ligand-lanthanide complexes.
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Andiappan K, Sanmugam A, Deivanayagam E, Karuppasamy K, Kim HS, Vikraman D,


Andiappan K, Sanmugam A, Deivanayagam E, Karuppasamy K, Kim HS, Vikraman D, (click to view)

Andiappan K, Sanmugam A, Deivanayagam E, Karuppasamy K, Kim HS, Vikraman D,

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Scientific reports 2018 02 148(1) 3054 doi 10.1038/s41598-018-21366-1

Abstract

A Schiff base ligand (SBL), N, N-bis (anthracen-9-ylmethylene) pyridine-2, 3-diamine, was synthesized through the condensation of 2,6-diaminopyridine and anthracene-9-carbaldehyde using a 1:2 ratio.H NMR spectra confirmed the observation of non-involvement aromatic carboxylic proton in SBL. A novel series of lanthanide (i.e., praseodymium (Pr), erbium (Er), and ytterbium (Yb))-based SBL metal complexes was successfully synthesized, and their functional groups were elaborately demonstrated using UV-visible, Fourier transform infrared (FT-IR), and fluorescence spectroscopy analyses. FT-IR spectral studies revealed that SBL behaved as a bidentate ligand and it was structured with metal ions by the two azomethine nitrogens. The synthesized SBL-based metal complexes were elaborately performed for cytotoxicity activity versus Vero, human breast cancer (MCF7), and cervical (HeLa) anticancer cell lines.

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