Advertisement

 

 

Incidence of sexually transmitted infections before and after Pre-Exposure Prophylaxis for HIV: a cohort study.

Incidence of sexually transmitted infections before and after Pre-Exposure Prophylaxis for HIV: a cohort study.
Author Information (click to view)

Nguyen VK, Greenwald ZR, Trottier H, Cadieux M, Goyette A, Beauchemin M, Charest L, Longpré D, Lavoie S, Tossa HG, Thomas R,


Nguyen VK, Greenwald ZR, Trottier H, Cadieux M, Goyette A, Beauchemin M, Charest L, Longpré D, Lavoie S, Tossa HG, Thomas R, (click to view)

Nguyen VK, Greenwald ZR, Trottier H, Cadieux M, Goyette A, Beauchemin M, Charest L, Longpré D, Lavoie S, Tossa HG, Thomas R,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

AIDS (London, England) 2017 12 12() doi 10.1097/QAD.0000000000001718

Abstract
OBJECTIVE
Use of Pre-Exposure Prophylaxis (PrEP) for HIV raises concerns about sexually transmitted infection (STI) incidence due to decreased condom use among men who have sex with men (MSM). This study examines whether PrEP is associated with STIs in the 12-months following PrEP prescription relative to the 12-months prior to PrEP and if STI rates are higher among PrEP users relative to individuals receiving Post-Exposure Prophylaxis (PEP).

DESIGN
Retrospective cohort study including PrEP users with >12 months of follow-up before PrEP prescription and individuals receiving PEP from 2010-2015 at Clinique l’Actuel (Montréal, Canada).

METHODS
Incidence of Chlamydia, Gonorrhoea, Syphilis and Hepatitis C Virus over 12-months was compared before and after PrEP; and for PrEP versus PEP users using Poisson models to generate Incidence Rate Ratios (IRRs) with 95% Confidence Intervals (CIs) and adjusted IRRs (aIRRs) controlling for frequency of STI screening visits. Models comparing PrEP and PEP users were further adjusted for age and education.

RESULTS
109 PrEP and 86 PEP users were included. Increased rates of STIs were observed in the 12-months after PrEP relative to the 12-months prior (IRR: 1.72, CI: 1.22-2.41; aIRR: 1.39, CI: 0.98-1.96). PrEP users were also at higher STI risk relative to PEP users (IRR: 2.18, CI: 1.46-3.24; aIRR: 1.76, CI: 1.14-2.71).

CONCLUSION
Increased rates of STIs among individuals after initiation of PrEP may suggest a greater risk behaviours during the first year on PrEP. Further studies are needed to measure long-term trends in STI acquisition following PrEP initiation.

Submit a Comment

Your email address will not be published. Required fields are marked *

12 − 7 =

[ HIDE/SHOW ]