Advertisement

 

 

Incidence rate of community-acquired pneumonia in adults: a population-based prospective active surveillance study in three cities in South America.

Incidence rate of community-acquired pneumonia in adults: a population-based prospective active surveillance study in three cities in South America.
Author Information (click to view)

Lopardo GD, Fridman D, Raimondo E, Albornoz H, Lopardo A, Bagnulo H, Goleniuk D, Sanabria M, Stamboulian D,


Lopardo GD, Fridman D, Raimondo E, Albornoz H, Lopardo A, Bagnulo H, Goleniuk D, Sanabria M, Stamboulian D, (click to view)

Lopardo GD, Fridman D, Raimondo E, Albornoz H, Lopardo A, Bagnulo H, Goleniuk D, Sanabria M, Stamboulian D,

Advertisement

BMJ open 2018 04 108(4) e019439 doi 10.1136/bmjopen-2017-019439
Abstract
OBJECTIVE
To determine the incidence rate and mortality of community-acquired pneumonia (CAP) in adults in three cities in Latin America during a 3-year period.

DESIGN
Prospective population-based surveillance study.

SETTING
Healthcare facilities (outpatient centres and hospitals) in the cities of General Roca (Argentina), Rivera (Uruguay) and Concepción (Paraguay).

PARTICIPANTS
2302 adults aged 18 years and older with CAP were prospectively enrolled between January 2012 and March 2015.

MAIN OUTCOME MEASURES
Incidence rates of CAP in adults, predisposing conditions for disease, mortality at 14 days and at 1 year were estimated. Incidence rate of CAP, within each age group, was calculated by dividing the number of cases by the person-years of disease-free exposure time based on the last census; incidence rates were expressed per 1000 person-years.

RESULTS
Median age of participants was 66 years, 46.44% were men, 68% were hospitalised. Annual incidence rate was 7.03 (95% CI 6.64 to 7.44) per 1000 person-years in General Roca, 6.33 (95% CI 5.92 to 6.78) per 1000 person-years in Rivera and 1.76 (95% CI 1.55 to 2.00) per 1000 person-years in Concepción. Incidence rates were highest in participants aged over 65 years. 82.4% had at least one predisposing condition and 48% had two or more (multimorbidity). Chronic heart disease (43.6%) and smoking (37.3%) were the most common risk factors. 14-day mortality rate was 12.1% and 1-year mortality was 24.9%. Multimorbidity was associated with an increased risk of death at 14 days (OR 2.91; 95% CI 2.23 to 3.80) and at 1 year (OR 3.00; 95% CI 2.44 to 3.70).

CONCLUSIONS
We found a high incidence rate of CAP in adults, ranging from 1.76 to 7.03 per 1000 person-years, in three cities in South America, disclosing the high burden of disease in the region. Efforts to improve prevention strategies are needed.

Submit a Comment

Your email address will not be published. Required fields are marked *

5 × three =

[ HIDE/SHOW ]