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Increased level and interferon-γ production of circulating natural killer cells in patients with scrub typhus.

Increased level and interferon-γ production of circulating natural killer cells in patients with scrub typhus.
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Kang SJ, Jin HM, Cho YN, Kim SE, Kim UJ, Park KH, Jang HC, Jung SI, Kee SJ, Park YW,


Kang SJ, Jin HM, Cho YN, Kim SE, Kim UJ, Park KH, Jang HC, Jung SI, Kee SJ, Park YW, (click to view)

Kang SJ, Jin HM, Cho YN, Kim SE, Kim UJ, Park KH, Jang HC, Jung SI, Kee SJ, Park YW,

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PLoS neglected tropical diseases 2017 07 2711(7) e0005815 doi 10.1371/journal.pntd.0005815
Abstract
BACKGROUND
Natural killer (NK) cells are essential immune cells against several pathogens. Not much is known regarding the roll of NK cells in Orientia tsutsugamushi infection. Thus, this study aims to determine the level, function, and clinical relevance of NK cells in patients with scrub typhus.

METHODOLOGY/PRINCIPAL FINDINGS
This study enrolled fifty-six scrub typhus patients and 56 health controls (HCs). The patients were divided into subgroups according to their disease severity. A flow cytometry measured NK cell level and function in peripheral blood. Circulating NK cell levels and CD69 expressions were significantly increased in scrub typhus patients. Increased NK cell levels reflected disease severity. In scrub typhus patients, tests showed their NK cells produced higher amounts of interferon (IFN)-γ after stimulation with interleukin (IL)-12 and IL-18 relative to those of HCs. Meanwhile, between scrub typhus patients and HCs, the cytotoxicity and degranulation of NK cells against K562 were comparable. CD69 expressions were recovered to the normal levels in the remission phase.

CONCLUSIONS
This study shows that circulating NK cells are activated and numerically increased, and they produced more IFN-γ in scrub typhus patients.

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