European journal of endocrinology 2016 12 08() pii EJE-16-0815
Diabetes mellitus and obesity are well-known risk factors associated with obstructive sleep apnea(OSA). Cushing’s syndrome (CS) is also characterised by obesity and diabetes mellitus. However, the association between CS and OSA remains unclear. Therefore, we investigated the possible associations between CS and OSA in this study.
PATIENTS AND METHODS
Thirty female patients with newly diagnosed active CS and 30 age-, gender and body mass index (BMI)-matched female controls were included in this study. All of the participants were evaluated by an overnight polysomnography. OSAwas defined as having anapnea-hypopnea index (AHI) score of ≥5 events/hour. BMI was recorded and iInsulin resistance was calculated by homeostasis model assessment (HOMA) scores. Fasting serum cortisol was also determined.
The mean HOMA (P=0.046) and AHI (P=0.028) scores were higher in patients with CS compared to the control subjects. AHI was positively correlated with the HOMA scores (r=0.281, P=0.046) in both groups. Linear regression analysis showed that serum cortisol remained as an independent predictor for AHI after controlling for BMI and HOMA score (P<0.001).The frequency of OSA was higher (50% vs. 23%, P=0.003) in patients with CS compared to the control subjects. CONCLUSIONS
The risk of OSA increased in patients with CS compared to control subjects with similar ages and BMI levels.Hypercortisolemia is an independent risk factor for developing OSA. The presence of OSA needs to be considered in patients with CS.