Advertisement

 

 

Increased resting energy expenditure and insulin resistance in male patients with moderate-to severe obstructive sleep apnoea.

Increased resting energy expenditure and insulin resistance in male patients with moderate-to severe obstructive sleep apnoea.
Author Information (click to view)

Brúsik M, Štrbová Z, Petrášová D, Pobeha P, Kuklišová Z, Tkáčová R, Joppa P,


Brúsik M, Štrbová Z, Petrášová D, Pobeha P, Kuklišová Z, Tkáčová R, Joppa P, (click to view)

Brúsik M, Štrbová Z, Petrášová D, Pobeha P, Kuklišová Z, Tkáčová R, Joppa P,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

Physiological research 2016 08 1965(6) 969-977
Abstract

Obstructive sleep apnoea (OSA) has been associated with disturbances in energy metabolism and insulin resistance, nevertheless, the links between OSA severity, resting energy expenditure (REE) and insulin resistance (homeostasis model assessment, HOMA-IR) remained unexplored. Therefore, we investigated the effects of OSA severity on REE, and relationships between REE and HOMA-IR in patients with OSA. Forty men [mean (SD) age 49.4 (11.4) years] underwent overnight polysomnography; REE was assessed using indirect calorimetry. REE adjusted for fat-free mass (FFM) was higher in patients with moderate-to severe OSA [n=24; body mass index (BMI) 31.1 (2.7) kg.m(-2); apnoea-hypopnoea index (AHI)>/=15 episodes.h(-1)] compared to participants with no clinically significant OSA (n=16; BMI 30.3 (2.2) kg.m(-2); AHI<15 episodes.h(-1)) [median (interquartile range) 30.4 (26.1-31.3) versus 25.8 (24.6-27.3) kcal.kg(-1).24 h(-1), p=0.005)]. AHI and oxygen desaturation index (ODI) were directly related to REE/FFM (p=0.001; p<0.001, respectively) and to HOMA-IR (p<0.001 for both). In stepwise multiple linear models, REE/FFM was independently predicted by ODI (p<0.001) and age (p=0.028) (R(2)=0.346); HOMA-IR was independently predicted by ODI only (p<0.001, R(2)=0.457). In conclusion, male patients with moderate-to severe OSA have increased REE paralleled by impaired insulin sensitivity. Severity of nocturnal intermittent hypoxia reflected by ODI is an independent predictor of REE/FFM and HOMA-IR.

Submit a Comment

Your email address will not be published. Required fields are marked *

5 + eleven =

[ HIDE/SHOW ]