A high incidence of translocation of the MLL gene at chromosome band 11q23 is the mutual link between acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Chemotherapies that target DNA topoisomerase to treat leukemia also exhibited similar translocations. There are several partner genes of MLL. The researchers have not comprehended the role of MLL fusion proteins in leukemogenesis yet. The outcome is adversely affected by the t(4;11) translocation, which is the most prevalent translocation in infant ALL. In infant ALL, researchers have found additional genetic changes, notably Ikaros alterations. Different types of myeloid leukemia in newborn children present as myelodysplastic and myeloproliferative syndromes, which might be linked with constitutional disorders. The study will take all leukemia in infants into consideration, but it will emphasize leukemias with MLL gene translocations.
Link:theoncologist.onlinelibrary.wiley.com/doi/10.1634/theoncologist.4-3-225
