The effect of infection complications in patients with trauma on in-hospital mortality differs by trauma severity, according to a study published in Scientific Reports. However, the impact of infection on the prognosis of trauma patients according to severity remains unclear. Investiga- tors assessed the impact of infection complica- tions on in-hospital mortality among patients with trauma according to severity via a retro- spective cohort review using a nationwide reg- istry. Patients aged 18 and older with blunt or penetrating trauma who were admitted to ICUs or general wards between 2004 and 2017 were included. The study team compared the baseline characteristics and outcomes between patients with and without infection and conducted a multivariable logistic regression analysis to in- vestigate the impact of infection on in-hospital mortality according to trauma severity, which was classified as mild [Injury Severity Score (ISS) < 15], moderate (ISS 15-29), or severe (ISS ≥ 30). Among the 150,948 patients in this study, 10,338 (6.8%) developed infections. Patients with infection had greater in-hospital mortality than patients without infection (1,085 [10.5%] vs 2,898 [2.1%]).