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Inflammatory infiltrates in parathyroid tumors.

Inflammatory infiltrates in parathyroid tumors.
Author Information (click to view)

Haglund F, Hallström BM, Nilsson IL, Höög A, Juhlin CC, Larsson C,


Haglund F, Hallström BM, Nilsson IL, Höög A, Juhlin CC, Larsson C, (click to view)

Haglund F, Hallström BM, Nilsson IL, Höög A, Juhlin CC, Larsson C,

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European journal of endocrinology 2017 08 30177(6) 445-453 doi 10.1530/EJE-17-0277

Abstract
CONTEXT
Inflammatory infiltrates are sometimes present in solid tumors and may be coupled to clinical behavior or etiology. Infectious viruses contribute to tumorigenesis in a significant fraction of human neoplasias.

OBJECTIVE
Characterize inflammatory infiltrates and possible viral transcription in primary hyperparathyroidism.

DESIGN
From the period 2007 to 2016, a total of 55 parathyroid tumors (51 adenomas and 4 hyperplasias) with prominent inflammatory infiltrates were identified from more than 2000 parathyroid tumors in the pathology archives, and investigated by immunohistochemistry for CD4, CD8, CD20 and CD45 and scored as +0, +1 or +2. Clinicopathological data were compared to 142 parathyroid adenomas without histological evidence of inflammation. Transcriptome sequencing was performed for 13 parathyroid tumors (four inflammatory, 9 non-inflammatory) to identify potential viral transcripts.

RESULTS
Tumors had prominent germinal center-like nodular (+2) lymphocytic infiltrates consisting of T and B lymphocytes (31%) and/or diffuse (+1-2) infiltrates of predominantly CD8+ T lymphocytes (84%). In the majority of cases with adjacent normal parathyroid tissue, the normal rim was unaffected by the inflammatory infiltrates (96%). Presence of inflammatory infiltrates was associated with higher levels of serum-PTH (P = 0.007) and oxyphilic differentiation (P = 0.002). Co-existent autoimmune disease was observed in 27% of patients with inflammatory infiltrates, which in turn was associated with oxyphilic differentiation (P = 0.041). Additionally, prescription of anti-inflammatory drugs was associated with lower serum ionized calcium (P = 0.037).

CONCLUSIONS
No evidence of virus-like sequences in the parathyroid tumors could be found by transcriptome sequencing, suggesting that other factors may contribute to attract the immune system to the parathyroid tumor tissue.

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