ESS has had many complications, e.g., synechia formation. This meta-analysis investigated the effect of a novel chitosan-based dressing on preventing synechia and wound healing after ESS.

The researchers systematically searched various medical literature databases and included randomized controlled trials regarding the effect of novel chitosan-based dressing on ESS. The study outcomes included synechia, granulations, hemostasis, crusting sores, and infection.

Six RCTs, which involved 337 patients, were included in the meta-analysis. Compared with control intervention after ESS, chitosan-based gel dressing substantially inhibited synechia (risk ratio [RR] 0.28 [95% confidence interval {CI}, 0.15–0.54]; p = 0.0001), improved granulations (RR 1.47 [95% CI, 1.07–2.03]; p = 0.02), and hemostasis (RR 1.47 [95% CI, 1.07–2.03]; p = 0.02) but demonstrated no effect on crusting scores and infection (RR 0.88 [95% CI, 0.51–1.52]; p = 0.64).

The study concluded that compared with a control intervention, the chitosan-based dressing was associated with significantly reduced synechia and increased granulations and hemostasis but showed no influence on crusting and infection after ESS.