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Inhibition of influenza virus replication by adlay tea.

Inhibition of influenza virus replication by adlay tea.
Author Information (click to view)

Nagai E, Iwai M, Koketsu R, Sogabe R, Morimoto R, Suzuki Y, Ohta Y, Okuno Y, Ohshima A, Enomoto T, Isegawa Y,


Nagai E, Iwai M, Koketsu R, Sogabe R, Morimoto R, Suzuki Y, Ohta Y, Okuno Y, Ohshima A, Enomoto T, Isegawa Y, (click to view)

Nagai E, Iwai M, Koketsu R, Sogabe R, Morimoto R, Suzuki Y, Ohta Y, Okuno Y, Ohshima A, Enomoto T, Isegawa Y,

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Journal of the science of food and agriculture 2017 09 13() doi 10.1002/jsfa.8671
Abstract
BACKGROUND
This study was conducted to examine the antiviral activity of adlay tea and its components against influenza viruses. We further sought to clarify the mechanism by which these components regulate virus replication.

RESULTS
Adlay tea at a concentration suitable for drinking inhibited the multiplication of influenza viruses. Moreover, our results suggested that individual components of the tea had antiviral activities against the influenza A/PR/8/34 virus. Adlay tea inhibited multiplication of the H1N1, H3N2, and B types of influenza virus, including oseltamivir-resistant viruses. In addition, adlay tea inhibited influenza infection during the periods of virus adsorption to the cell and virus replication. Adlay tea did not suppress hemoagglutination inhibition (HI) or cell fusion, although it slightly inhibited virus binding to MDCK cells. Furthermore, our findings suggested that the antiviral compounds included in adlay tea were other ingredients rather than polyphenols, and there were several kinds of effective compounds in adlay tea that inhibit several steps of viral replication.

CONCLUSION
This study demonstrated that adlay tea had antiviral effects against influenza viruses. Our findings in adlay tea suggested that the polyphenols might have a small influence on its antiviral activity, and other ingredients might have more influence.

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