The number of adults who are overweight or obese and have type 2 diabetes is increasing rapidly throughout the United States. An estimated 35% of Americans are obese, and the number of U.S. diabetes cases has steadily risen to nearly 30 million. Alone, both obesity and diabetes can significantly increase healthcare costs, but these costs rise further when obesity and diabetes coexist. “It’s clear that strategies are needed to prevent obesity and diabetes, but it’s also important to improve how these conditions are managed when they develop,” says M. Sue Kirkman, MD.

In recent years, clinical trials have been launched to test intensive lifestyle interventions (ILIs) aimed at promoting long-term weight loss and increasing physical activity. These interventions are recommended for overweight and obese individuals with type 2 diabetes. “ILI provides patients with education, support, and follow-up so that they can incorporate changes into their daily lives and overcome potential hurdles to healthy eating and exercise,” explains Dr. Kirkman. However, while it has been assumed that ILI can reduce healthcare costs, few studies have examined the long-term effects of these interventions on costs among obese patients with diabetes.

Examining Long-Term Effects

The Action for Health in Diabetes (Look AHEAD) study is a randomized clinical trial that has sufficient size and duration to test whether ILI influences long-term healthcare use and costs. A recent study in Diabetes Care was conducted in more than 5,000 overweight or obese adults with type 2 diabetes who participated in the Look AHEAD study. Patients were randomly assigned to an ILI that promoted weight loss or to a comparison group of diabetes support and education (DSE). The research team recorded use and costs of healthcare services across an average of 10 years.


According to the results, ILI correlated with an 11% reduction in annual hospitalizations, a 15% reduction in hospital days, and a 6% decrease in number of medications used. This resulted in annual cost savings of about 10% for hospitalizations and 7% for medications (Table 1 and Table 2). ILI produced an average relative per-person 10-year cost savings of $5,280, but researchers noted that these savings were not evident among patients with a history of cardiovascular disease (CVD).

Improving Measures of Health

“Although the Look AHEAD study showed that ILI did not significantly reduce the overall risk of major CVD events, it did show that ILI improves many measures of health,” explains Dr. Kirkman. “These included markers of diabetes control, blood pressure, plasma lipid levels, sleep quality, physical function, and depression.” The effects of these factors varied in magnitude and duration, and some were not sustained throughout follow-up, but each could be associated with reduced healthcare needs.

In previous research, healthcare costs associated with obesity and diabetes have been shown to accelerate in later life. In the Diabetes Care study, researchers noted that the increased outpatient costs among ILI participants with prior CVD were not triggered by an imbalance in CVD events. Annual outpatient costs were 22% higher among ILI recipients than among DSE participants before CVD events occurred. It is still unclear as to why ILI may affect costs differently among participants with and without a CVD history. Regardless, the study results imply that ILI is most beneficial to overweight and obese individuals with diabetes before CVD is diagnosed.

Assessing the Implications

Future follow-up of the Look AHEAD cohort is expected and will likely assess whether ILI has a legacy effect during the oldest years of life, a time when healthcare costs tend to be highest. Dr. Kirkman says that policy makers need to explore reimbursement issues with these interventions. “ILI is time-consuming and requires input and care from multiple providers, many of whom are non-physicians, in order to be effective,” she says. “Reimbursement for ILI must improve in order for these programs to be used more frequently and to their fullest potential.”

Dr. Kirkman also says that findings of the Diabetes Care study illustrate that clinicians cannot take a one-size-fits-all approach to treating obese and overweight people with diabetes. “Each patient with diabetes will respond differently to the interventions they’re exposed to,” she says. “Clinicians need to take a more holistic approach when managing patients and must also consider the costs they will incur from hospitalizations and medications as well as outpatient services they’ll need. ILI has great potential to improve the care of patients with diabetes. The next step is to find ways to improve reimbursement


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