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Internal limiting membrane peeling and gas tamponade for myopic foveoschisis: a systematic review and meta-analysis.

Internal limiting membrane peeling and gas tamponade for myopic foveoschisis: a systematic review and meta-analysis.
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Meng B, Zhao L, Yin Y, Li H, Wang X, Yang X, You R, Wang J, Zhang Y, Wang H, Du R, Wang N, Zhan S, Wang Y,


Meng B, Zhao L, Yin Y, Li H, Wang X, Yang X, You R, Wang J, Zhang Y, Wang H, Du R, Wang N, Zhan S, Wang Y, (click to view)

Meng B, Zhao L, Yin Y, Li H, Wang X, Yang X, You R, Wang J, Zhang Y, Wang H, Du R, Wang N, Zhan S, Wang Y,

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BMC ophthalmology 2017 09 0817(1) 166 doi 10.1186/s12886-017-0562-8
Abstract
BACKGROUND
Myopic foveoschisis (MF) is among the leading causes of visual loss in high myopia. However, it remains controversial whether internal limiting membrane (ILM) peeling or gas tamponade is necessary treatment option for MF.

METHODS
PubMed, EMBASE, CBM, CNKI, WANFANG DATA and VIP databases were systematically reviewed. Outcome indicators were myopic foveoschisis resolution rate, visual acuity improvement and postoperative complications.

RESULTS
Nine studies that included 239 eyes were selected. The proportion of resolution of foveoschisis was higher in ILM peeling group than non-ILM peeling group (OR = 2.15, 95% CI: 1.06-4.35; P = 0.03). The proportion of postoperative complications was higher in Tamponade group than non-Tamponade group (OR = 10.81, 95% CI: 1.26-93.02; P = 0.03). However, the proportion of visual acuity improvement (OR = 1.63, 95% CI: 0.56-4.80; P = 0.37) between ILM peeling group and non-ILM peeling group and the proportion of resolution of foveoschisis (OR = 1.80, 95% CI: 0.76-4.28; P = 0.18) between Tamponade group and non-Tamponade group were similar.

CONCLUSIONS
Vitrectomy with internal limiting membrane peeling could contribute to better resolution of myopic foveoschisis than non-peeling, however it does not significantly influence the proportion of visual acuity improvement and postoperative complications. Vitrectomy with gas tamponade is associated with more complications than non-tamponade and does not significantly influence the proportion of visual acuity improvement and resolution of myopic foveoschisis.

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