An international multidisciplinary initiative, jointly supported by the American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR), is underway to develop new rigorous classification criteria to identify patients with a high likelihood of Antiphospholipid Syndrome (APS) for research purposes. We applied evidence and consensus‐based approach to identify candidate criteria and develop a hierarchical organization of criteria within domains.

During Phase I, the APS classification criteria Steering Committee used systematic literature reviews and surveys of international APS physician-scientists to generate a comprehensive list of APS items. Using iterative item reduction techniques in Phase II, we initially reduced these items to 64 potential candidate criteria organized into ten clinical and laboratory domains and following item reduction methods resulted in 27 candidate criteria, hierarchically organized into six additive domains (laboratory, macrovascular, microvascular, obstetric, cardiac, and hematologic) for APS classification.

In conclusion, using data‐ and consensus‐driven methodology, we identified twenty‐seven APS candidate criteria in six clinical or laboratory domains. In the next phase, the proposed candidate criteria will be used for real‐world case collection, further refined, organized, and weighted to determine an aggregate score and threshold for APS classification.