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Intracerebroventricular infusion of an Angiotensin AT2 receptor agonist Novokinin aggravates some diabetes mellitus-induced alterations in Wistar rats.

Intracerebroventricular infusion of an Angiotensin AT2 receptor agonist Novokinin aggravates some diabetes mellitus-induced alterations in Wistar rats.
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Pechlivanova D, Petrov K, Grozdanov P, Nenchovska Z, Tchekalarova J, Stoynev A,


Pechlivanova D, Petrov K, Grozdanov P, Nenchovska Z, Tchekalarova J, Stoynev A, (click to view)

Pechlivanova D, Petrov K, Grozdanov P, Nenchovska Z, Tchekalarova J, Stoynev A,

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Canadian journal of physiology and pharmacology 2017 10 13() doi 10.1139/cjpp-2017-0428
Abstract

Cumulative data suggest the significant role of the Renin – Angiotensin System in the development of the pathological consequences of diabetes mellitus (DM). Newly synthesized AT2 receptor agonists gained importance as a target for creating new antihypertensives. The aim of the present work was to study the effects of a peptide AT2 agonist Novokinin, infused intracerebroventricularly, on the consequences of the streptozotocin-induced type 1 DM (T1 DM) in Wistar rats. Food and water consumption, body weight, urine excretion (metabolic cages), motor activity (open field test), anxiety (elevated plus maze), nociception (paw pressure analgesimeter test), spatial memory (T-maze alternation test) and plasma levels of glucose and corticosterone (ELISA) were assessed two weeks after the T1 DM induction. Novokinin increased water and food consumption, and urine output and reduced weight gain in the control rats. Diabetic rats demonstrated hyperalgesia, increased level of plasma corticosterone, decreased motor and exploratory activity, impaired spatial memory. Novokinin infusion increased water intake, diuresis and mortality rate, decreased food intake, exacerbated diabetes-induced hyperalgesia and provoked anxiety-like behavior but improved spatial memory in diabetic rats. These initial data suggest that angiotensin AT2 receptors participate in the pathogenesis of T1 DM-induced complications in the function of the nervous system.

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