Advertisement

 

 

Investigation of function and regulation of the YB-1 cellular factor in HIV replication.

Investigation of function and regulation of the YB-1 cellular factor in HIV replication.
Author Information (click to view)

Jung YM, Yu KL, Park SH, Lee SD, Kim MJ, You JC,


Jung YM, Yu KL, Park SH, Lee SD, Kim MJ, You JC, (click to view)

Jung YM, Yu KL, Park SH, Lee SD, Kim MJ, You JC,

Advertisement

BMB reports 2018 02 12() pii

Abstract

Y-box binding protein 1 (YB-1) is a member of the cold-shock domain (CSD) protein superfamily. It participates in a wide variety of cellular events, including transcription, RNA splicing, translation, DNA repair, drug resistance, and stress responses. We investigated putative functions of YB-1 in HIV-1 replication. Functional studies using overexpression or knockdown of YB-1 in conjunction with transfection of proviral DNA showed that YB-1 enhances virus production. We found YB-1 regulates HIV-1 production by stimulating viral transcription using HIV-1 LTR sequence U3RU5 with Luciferase assay. We identified also a specific region from amino acids 1 to 324 of YB-1 as necessary for the participation of the protein in the production of virions.

Submit a Comment

Your email address will not be published. Required fields are marked *

13 − eleven =

[ HIDE/SHOW ]