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Is diacerein an alternative for the treatment of osteoarthritis?

Is diacerein an alternative for the treatment of osteoarthritis?
Author Information (click to view)

Alegría A, Irarrázaval S,


Alegría A, Irarrázaval S, (click to view)

Alegría A, Irarrázaval S,

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Medwave 2017 10 1217(8) e7041 doi 10.5867/medwave.2017.08.7041
Abstract
INTRODUCTION
Among the possibilities for the management of osteoarthritis, different pharmacological alternatives have been proposed, being diacerein one of them due to its anti-inflammatory effect. However, diacerein clinical utility is not clear.

METHODS
To answer this question, we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach.

RESULTS AND CONCLUSION
We concluded diacerein probably leads to a slight reduction in pain, but would not improve functionality among patients with knee osteoarthritis, and can frequently present diarrhea as an adverse effect.

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