Mechanical ventilation can be a life-saving strategy for certain severely ill patients, but it is not without risks. Efforts to reduce mechanical ventilation durations in order to minimize these morbidities, particularly in the present atmosphere of heightened staffing in US critical care units overnight, may make nighttime extubation more likely. Understanding the safety and efficacy of this approach is so critical. The available research on this topic was restricted to two retrospective investigations released in 2016 with contradictory conclusions. In this light, researchers examined and assessed its interpretation, considering the next steps, and ultimately presented the current practice in order to answer the question, “Is it safe to extubate patients overnight?”