For a study, researchers sought to compare the pathophysiology of the surgically excised group with the group that had a spontaneous resolution to evaluate the pathophysiology of the parameatal urethral cyst (PUC).

All patients with PUC who were ≤15 years old were retrospectively evaluated. At first, no therapy was given to any of the patients; they were all only observed. Family preference was a sign that surgery was necessary. Sex, age, symptoms, clinical history, and pathological examination results were all taken into consideration while analyzing the patients.

A total of 54 boys needed PUC at the hospital. Seven (13.3%) instances involving newborns were present at the median presentation age of 35 months (IQR: 12–50). About 38 (70.4%) of the patients required surgical excision, whereas 12 (22.2%) spontaneously improved during observation, 1, (1.9%) remained unresolved after observation, and 3, (5.6%) were lost to follow-up. In comparison to the spontaneous resolution group (1.5 mm median, IQR 1-2.5) (P<.0001), the surgical excision  (5 mm median, IQR 3-5) group’s median PUC size at the initial visit was substantially higher. PUCs with a diameter of ≥5 mm in the investigation did not spontaneously resolve.

It was the biggest PUC research yet carried out by a single institute. According to the study, 22% of PUCs spontaneously resolved, and PUCs <5 mm could do so as well. The outcomes advise individuals with asymptomatic PUC< 5 mm should be monitored for at least 5.5 months. Contrarily, for symptomatic PUC ≥5 mm, they advised surgical excision in accordance with the family’s desire.

Reference: goldjournal.net/article/S0090-4295(22)00442-3/fulltext