Researchers concluded that to evaluate the rate of adverse reaction toward rabies vaccine in China, explore its characteristics, and provide a scientific and objective basis for future policy decisions.
Literature on the rate of adverse reaction to rabies vaccine in China was retrieved and collected in CNKI, Wanfang, VIP databases, PubMed, and Embase. A meta-analysis was carried out then.
Researchers included thirty-five articles. The combined rate of adverse reaction to rabies vaccine was 5.6%. Adverse reactions to rabies vaccine were 11.3% and 4.5% before and after 2011, 5.3% and 7.1% in the eastern and midwestern regions, 13.2%, 25.5%, and 3.7% in the tertiary hospitals, secondary hospitals, and primary medical institutions, respectively. And 13.3% were in the areas where the Changchun immortal vaccine was used. The combined rate of adverse reaction to rabies vaccine inoculated in the Changsheng vaccine area was 5.1%.
The rate of adverse reactions to rabies vaccine in China has decreased dramatically. The rate of negative response to rabies vaccine in the midwestern regions is higher than that of the eastern areas. The primary medical institutions are lower than the counterpart in the tertiary and secondary hospitals.