ISC 2013: A Novel Approach to Treating Stroke Patients


The Particulars: Currently, the only treatment to relieve swelling of the brain caused by a severe ischemic stroke is craniotomy. A novel intravenous formulation of glyburide (RP-1127), a diabetes drug, may prevent such swelling.

Data Breakdown: For a study, 10 patients at risk for malignant infarction because of a severe ischemic stroke received RP-1127, followed by continuous infusion for 72 hours. Rates for malignant edema, 30-day mortality, and disability were significantly less than those observed in previous research. No serious side effects were attributed to the drug.

Take Home Pearl: RP-1127, a novel intravenous diabetes drug, appears to significantly decrease the rate of deadly brain swelling in patients with severe ischemic stroke.


  1. International Stroke Conference 2013 | Physician's Weekly for Medical News, Journals & Articles - [...] A Novel Approach to Treating Stroke Patients [...]

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