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Iso-osmolar contrast media and adverse renal and cardiac events after percutaneous cardiovascular intervention.

Iso-osmolar contrast media and adverse renal and cardiac events after percutaneous cardiovascular intervention.
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McCullough PA, David G, Todoran TM, Brilakis ES, Ryan MP, Gunnarsson C,


McCullough PA, David G, Todoran TM, Brilakis ES, Ryan MP, Gunnarsson C, (click to view)

McCullough PA, David G, Todoran TM, Brilakis ES, Ryan MP, Gunnarsson C,

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Journal of comparative effectiveness research 2017 11 09() doi 10.2217/cer-2017-0052
Abstract
AIM
To assess the relationship between type of contrast media (CM), iso-osmolar contrast media (IOCM) or low-osmolar contrast media (LOCM), and major adverse renal and cardiovascular events (MARCE).

MATERIALS & METHODS
Coronary or peripheral angioplasty visits were stratified into CM cohorts: IOCM or LOCM. Multivariable regression analysis used hospital fixed effects to assess the relationship between MARCE events and type of CM.

RESULTS
Among 333,533 visits (357 hospitals), the incidence of MARCE was 7.41%. After controlling for observable and unobservable time invariant within-hospital characteristics, administration of IOCM versus LOCM was associated with a 0.69% absolute and 9.32% relative risk reduction in MARCE rate.

CONCLUSION
Our study indicates that as compared with LOCM, IOCM may be associated with reduction of MARCE events in coronary or peripheral angioplasty patients.

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