WEDNESDAY, June 6, 2018 (HealthDay News) — Job strain is associated with an increased risk of death among men with cardiometabolic disease, according to research published online June 5 in The Lancet Diabetes & Endocrinology.

Mika Kivimäki, F.Med.Sci., from the Helsinki Institute of Life Science, and colleagues examined the correlation between work stress and mortality using data from seven cohort studies in the Individual-Participant-Data Meta-analysis in Working Populations (IPD-Work) consortium initiated between 1985 and 2002. Work stress was classified as job strain or effort-reward imbalance. Individual-level data were extracted on prevalent cardiometabolic diseases at baseline.

The researchers found that 3,441 of 102,633 individuals with 1,423,753 person-years at risk had prevalent cardiometabolic disease at baseline and 3,841 died during follow-up. Age-standardized mortality rates were substantially higher in those with versus those without job strain among men with cardiometabolic disease (mortality difference, 52.1 per 10,000 person-years; multivariable-adjusted hazard ratio, 1.68). This difference in mortality was almost as great as that for current versus former smoking (78.1 per 10,000 person-years) and greater than those due to hypertension, high total cholesterol concentration, obesity, physical inactivity, and high alcohol consumption relative to the corresponding lower-risk groups (mortality difference, 5.9 to 44 per 10,000 person-years).

“In men with cardiometabolic disease, the contribution of job strain to risk of death was clinically significant and independent of conventional risk factors and their treatment, and measured lifestyle factors,” the authors write.

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