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June 2017 Briefing – Pathology

June 2017 Briefing – Pathology
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Here are what the editors at HealthDay consider to be the most important developments in Pathology for June 2017. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

T1DM Patients With Active β-Cell Function Differ Immunologically

FRIDAY, June 30, 2017 (HealthDay News) — Patients with remaining endogenous β-cell function after a decade of living with type 1 diabetes tend to have much higher levels of interleukin-35 (IL-35) than other patients with long-standing type 1 diabetes, according to a study published in the June issue of Diabetes Care.

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Genes Responsible for Crohn’s, Ulcerative Colitis Identified

FRIDAY, June 30, 2017 (HealthDay News) — Researchers say they’ve come closer to pinpointing genes linked with inflammatory bowel diseases (IBDs) such as Crohn’s and ulcerative colitis. The research was published online June 28 in Nature.

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Dutasteride Associated With Metabolic Safety Concerns

FRIDAY, June 30, 2017 (HealthDay News) — Dutasteride for the treatment of benign prostatic hyperplasia may induce imbalance in metabolic function, according to a study published online June 21 in Hormone Molecular Biology and Clinical Investigation.

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Nanoallergen Platform Can Identify Immunogenic Epitopes

FRIDAY, June 30, 2017 (HealthDay News) — A novel nanoallergen platform has been developed, which can identify the immunogenic epitopes in the major peanut allergy protein Ara h2, according to research published online June 21 in Scientific Reports.

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In HIV, Greater BMD Decline for Immediate Versus Delayed ART

FRIDAY, June 30, 2017 (HealthDay News) — Immediate antiretroviral (ART) initiation at HIV diagnosis is associated with greater bone mineral density (BMD) declines compared with deferred initiation, according to a study published online June 26 in the Journal of Bone and Mineral Research.

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Genetic, Environmental Exposure Tied to Islet Autoantibodies

FRIDAY, June 30, 2017 (HealthDay News) — For children, genetic factors and environmental exposures are associated with islet autoantibodies, according to a study published online June 23 in Diabetes Care.

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Doctors Urged to Take Care With Electronic Communications

THURSDAY, June 29, 2017 (HealthDay News) — Care should be taken when conveying electronic messages to patients, according to a report published by the American Medical Association (AMA).

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Health of the Nation Presented in 40th Annual CDC Report

THURSDAY, June 29, 2017 (HealthDay News) — The health of the United States is summarized in the 40th annual report published by the U.S. Centers for Disease Control and Prevention.

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Higher IQ in Childhood Associated With a Longer Life

THURSDAY, June 29, 2017 (HealthDay News) — A high IQ in childhood is associated with lower risk of mortality due to coronary heart disease and stroke, cancers related to smoking, respiratory diseases, digestive diseases, injury, and dementia, according to a study published online June 28 in The BMJ.

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Melanoma Diagnoses Can Vary Widely Among Pathologists

THURSDAY, June 29, 2017 (HealthDay News) — Pathologists can vary widely when assessing skin biopsies for melanoma, particularly when the case is not clear-cut, according to a study published online June 28 in The BMJ.

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Even Low Levels of Pollution Raise Mortality Risk for Seniors

THURSDAY, June 29, 2017 (HealthDay News) — Air pollution may shorten the lives of American seniors, even in areas where levels fall below national safety standards, according to a study published in the June 29 issue of the New England Journal of Medicine.

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Tryptophan May Be Marker for Diabetic Nephropathy

THURSDAY, June 29, 2017 (HealthDay News) — For patients with diabetes and chronic kidney disease (CKD), a lower level of tryptophan (Trp) is associated with rapid decline in estimated glomerular filtration rate (eGFR), according to a study published online June 26 in the Journal of Diabetes Investigation.

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Number of Hospitalizations for Heart Failure Declining

WEDNESDAY, June 28, 2017 (HealthDay News) — The number of Americans hospitalized for heart failure has dropped substantially since 2002, but blacks still face higher risks, according to a study published online June 27 in Circulation: Cardiovascular Quality and Outcomes.

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Case Report: Development of RA in Transplanted Hands

WEDNESDAY, June 28, 2017 (HealthDay News) — In a case report published online June 27 in the Annals of Internal Medicine, rheumatoid arthritis is diagnosed in the hands of a patient who underwent bilateral hand transplantation.

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Shift Work May Affect the Body’s Ability to Repair DNA Damage

TUESDAY, June 27, 2017 (HealthDay News) — Capacity to repair everyday damage to cell DNA could be impaired in people who work the night shift, which may be due to melatonin suppression, according to a study published online June 26 in Occupational & Environmental Medicine.

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Estimated Prevalence of Diabetes 10.9 Percent in China

TUESDAY, June 27, 2017 (HealthDay News) — The prevalence of diabetes is 10.9 percent in China, but only 36.5 percent of those with diabetes are aware of their diagnosis, according to research published online June 27 in the Journal of the American Medical Association.

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suPAR Protein Levels Impact CKD Risk With APOL1 Variants

TUESDAY, June 27, 2017 (HealthDay News) — Plasma suPAR levels independently predict renal function decline in individuals with apolipoprotein L1 (APOL1) risk variants, according to a study published online June 26 in Nature Medicine.

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Reduced Cancer-Independent Life Expectancy in Head, Neck Cancer

TUESDAY, June 27, 2017 (HealthDay News) — Patients with head and neck cancer have reduced life expectancy, independent of cancer, according to a study published online June 22 in Head & Neck.

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Bacterial Colonization Linked to Food Sensitization, Allergy

TUESDAY, June 27, 2017 (HealthDay News) — There is a correlation between bacterial colonization and food sensitization and allergy in young children, according to a study published online June 20 in Allergy.

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Novel Score Can Assess Severity of Hidradenitis Suppurativa

TUESDAY, June 27, 2017 (HealthDay News) — A novel score can assess the severity of hidradenitis suppurativa (HS), according to a study published online June 21 in the British Journal of Dermatology.

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Many Adverse Events Related to Cosmetics Go Unreported

TUESDAY, June 27, 2017 (HealthDay News) — Health problems related to cosmetics are underreported, according to a study published online June 26 in JAMA Internal Medicine.

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Whole-Genome Sequencing of Uncertain Clinical Utility

TUESDAY, June 27, 2017 (HealthDay News) — Whole-genome sequencing of healthy people reveals that while some are at risk for rare genetic diseases, the implications remain unknown, according to a study published online June 26 in the Annals of Internal Medicine.

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Sound Progress Made Toward Global Containment of Poliovirus

MONDAY, June 26, 2017 (HealthDay News) — With the eradication of wild poliovirus type 2 in 2015, progress has been made toward containment of the virus, according to research published in the June 23 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report.

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Rate of Hip Fracture Declining in End-Stage Renal Disease

MONDAY, June 26, 2017 (HealthDay News) — For patients with end-stage renal disease (ESRD), the rate of hip fracture decreased from 2003 to 2011, according to a study published online June 22 in the Journal of Bone and Mineral Research.

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Immune Profile Differs During Symptom Flare, Free in IBS-D

MONDAY, June 26, 2017 (HealthDay News) — For patients with irritable bowel syndrome with diarrhea (IBS-D), interferon-γ concentrations and THELPER cells are inhibited during symptom flare, according to a research letter published online June 10 in Gut.

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Similar Skin Cancer Incidence Seen With Teledermatology

MONDAY, June 26, 2017 (HealthDay News) — The incidence of skin cancer is similar for patients evaluated by store-and-forward (SAF) teledermatology or face-to-face (F2F) consultation, according to a study published online June 20 in the International Journal of Dermatology.

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Longer Survival for Midostaurin + Chemotherapy in AML With FLT3

MONDAY, June 26, 2017 (HealthDay News) — For patients with acute myeloid leukemia (AML) and a FLT3 mutation, midostaurin plus chemotherapy is associated with prolonged overall and event-free survival, according to a study published online June 23 in the New England Journal of Medicine.

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HIV Testing Inadequate in Young Men Who Have Sex With Men

MONDAY, June 26, 2017 (HealthDay News) — Few young men who have sex with men (MSM) receive HIV testing, although they account for most new diagnoses, according to research published in the June 23 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report.

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Review Links Conjugated Linoleic Acid Supplementation to CRP

FRIDAY, June 23, 2017 (HealthDay News) — Conjugated linoleic acid (CLA) supplementation is associated with an increase in serum C-reactive protein (CRP) concentration, according to a review and meta-analysis published online May 29 in Cardiovascular Therapeutics.

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Family History Questionnaire Ups Genetic Counseling for CRC

FRIDAY, June 23, 2017 (HealthDay News) — For patients undergoing outpatient colonoscopy, a family history questionnaire (FHQ) sent by mail is associated with an increase in available family history and referral for genetic counseling, according to a study published online May 29 in the Journal of Digestive Diseases.

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Blood Test Can Detect GLUT1 Deficiency Syndrome

FRIDAY, June 23, 2017 (HealthDay News) — A simple and rapid blood test can detect GLUT1 deficiency syndrome (DS), according to a study published online May 26 in the Annals of Neurology.

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CDC: Zika Can Be Found in Placental, Fetal Tissue at Birth

FRIDAY, June 23, 2017 (HealthDay News) — Testing placental and fetal tissue after a child is born can confirm or rule out Zika infection, according to research published in the June 23 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report.

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High Levels of Brain Inflammation Seen in OCD

FRIDAY, June 23, 2017 (HealthDay News) — Patients with obsessive-compulsive disorder (OCD) have high levels of brain inflammation, according to a study published online June 21 in JAMA Psychiatry.

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Protective Association Identified for Asthma Against Sepsis

THURSDAY, June 22, 2017 (HealthDay News) — For patients with infections, those with asthma have reduced risk of sepsis, according to a letter to the editor published online May 22 in the American Journal of Respiratory and Critical Care Medicine.

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Occupation Tied to Risk of Vitamin D Deficiency

THURSDAY, June 22, 2017 (HealthDay News) — Shiftworkers, healthcare workers, and indoor workers are at high risk of developing vitamin D deficiency, according to a review published online June 22 in BMC Public Health.

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1991-2014 Saw Minimal Change in Health Spending Per State

THURSDAY, June 22, 2017 (HealthDay News) — From 1991 to 2014 there was minimal change in health spending by state, according to a study published online June 14 in Health Affairs.

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Many With Advanced Cancer Want Secondary Germline Findings Info

THURSDAY, June 22, 2017 (HealthDay News) — More than half of patients with advanced cancer who undergo tumor genomic profiling (TGP) are interested in learning their secondary germline findings, according to a study published online June 19 in the Journal of Oncology Practice.

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sRAGE Linked to Risk of Incident Diabetic Nephropathy

THURSDAY, June 22, 2017 (HealthDay News) — Serum levels of soluble receptor for advanced glycation end products (sRAGE) are associated with the risk of developing incident diabetic nephropathy (DN) in individuals with type 1 diabetes, according to a study published online June 19 in Diabetes Care.

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2006 to 2013 Saw Increase in ER Use for Herpes Zoster

THURSDAY, June 22, 2017 (HealthDay News) — From 2006 to 2013 there was an increase in the number of emergency department visits for herpes zoster (HZ), according to a study published online June 21 in JAMA Dermatology.

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Nearly 60 Percent With Conjunctivitis Fill Antibiotic Rx

THURSDAY, June 22, 2017 (HealthDay News) — Antibiotic prescriptions are filled by nearly 60 percent of patients newly diagnosed with acute conjunctivitis, according to a study published online June 14 in Ophthalmology.

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Clonal Hematopoiesis Linked to Coronary Heart Disease

THURSDAY, June 22, 2017 (HealthDay News) — The presence of clonal hematopoiesis of indeterminate potential (CHIP) is associated with coronary heart disease, according to research published online June 21 in the New England Journal of Medicine.

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Sharp Rise Among Women for Opioid-Related Hospitalizations

WEDNESDAY, June 21, 2017 (HealthDay News) — Opioid-related hospitalizations among women in the United States increased far faster than among men between 2005 and 2014, according to the U.S. Agency for Healthcare Research and Quality (AHRQ).

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Polymorphism in rs4343 of ACE Gene Linked to Migraine

WEDNESDAY, June 21, 2017 (HealthDay News) — Angiotensin I-converting enzyme (ACE) gene rs4343 polymorphism is associated with the risk of migraine, according to a letter to the editor published online June 18 in CNS Neuroscience & Therapeutics.

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Family Hx, Mutation Position Key Variables in BRCA1/2 Cancer Risk

WEDNESDAY, June 21, 2017 (HealthDay News) — Breast cancer risk peaks around the 40s for BRCA1 mutation carriers and around the 50s for BRCA2 carriers, with family history and mutation location significant factors in determining individual risk, according to a report published in the June 20 issue of the Journal of the American Medical Association.

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PSA Testing Frequency High in Control Arm of Screening Trial

WEDNESDAY, June 21, 2017 (HealthDay News) — Many men in the control arm of a screening trial undergo prostate-specific antigen testing during 15 years of follow-up, according to a study published in the July issue of The Journal of Urology.

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NSAID Use, Survival Link Varies With KRAS Status in CRC Patients

TUESDAY, June 20, 2017 (HealthDay News) — Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with improved survival among colorectal cancer (CRC) survivors with KRAS wild-type tumors, according to a study published online June 15 in the Journal of Clinical Oncology.

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Yoga May Be Able to ‘Reverse’ Stress-Inducing DNA Reactions

MONDAY, June 19, 2017 (HealthDay News) — The physical and mental health benefits of pursuits like yoga and meditation begin in the genes, according to research published online June 16 in the Frontiers in Immunology.

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Endurance Exercise Tied to Gastrointestinal Implications

MONDAY, June 19, 2017 (HealthDay News) — The risk of gastrointestinal injury and impaired function seems to increase along with the intensity and duration of exercise, according to a study published online June 7 in Alimentary Pharmacology & Therapeutics.

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Novel Biomarkers Identified for Prostate Cancer in Non-Blacks

MONDAY, June 19, 2017 (HealthDay News) — Novel biomarkers have been identified that may have utility for predicting prostate cancer in non-African-American men, according to a study published in the July issue of The Journal of Urology.

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Chronic Lyme Disease Treatments Tied to Serious Adverse Effects

MONDAY, June 19, 2017 (HealthDay News) — Serious bacterial infections have been documented during treatment for chronic Lyme disease, according to research published in the June 16 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report.

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Hydrotherapy Plus Conventional Drugs Beneficial in RA

MONDAY, June 19, 2017 (HealthDay News) — For patients with rheumatoid arthritis (RA), hydrotherapy in addition to conventional drugs is associated with improved antioxidant status, according to a study published online June 14 in the International Journal of Rheumatic Diseases.

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PCSK9 Increased in Females, Youth With Type 1 Diabetes

MONDAY, June 19, 2017 (HealthDay News) — Proprotein convertase subtilisin/kexin type 9 (PCSK9) is increased in young females and youth with type 1 diabetes (T1D), according to research published online June 6 in Diabetes Care.

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Donor Microbes Can Persist Long-Term After Fecal Transplant

FRIDAY, June 16, 2017 (HealthDay News) — Researchers say their small study, published online June 7 in Biofilms and Microbiomes, offers the first proof that therapeutic donor microbes remain for months or years in patients who’ve undergone fecal microbiota transplantation.

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Certain Criteria May Be Better Than Others in RA Assessment

FRIDAY, June 16, 2017 (HealthDay News) — For patients with rheumatoid arthritis (RA), the performances of the Clinical Disease Activity Index (CDAI) and Simplified Disease Activity Index (SDAI) appear to be better than that of the Disease Assessment Score of 28 joints—C-reactive protein (DAS-28-CRP), according to a study published online June 12 in the International Journal of Rheumatic Diseases.

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20 Percent of Hospital Patients Have Side Effects From Abx Rx

FRIDAY, June 16, 2017 (HealthDay News) — About 20 percent of U.S. hospital patients who receive antibiotics experience side effects from the drugs, according to research published online June 12 in JAMA Internal Medicine.

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Modified Colorectal CA Screening Score Improves Risk Prediction

FRIDAY, June 16, 2017 (HealthDay News) — A modified colorectal cancer screening score improves risk prediction of advanced neoplasia, according to a study published online May 31 in the Journal of Gastroenterology and Hepatology.

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Unusual Measles Outbreak Described in Ontario in Early 2015

FRIDAY, June 16, 2017 (HealthDay News) — Eighteen cases of measles were recorded as part of an unusual outbreak in Ontario, Canada, in early 2015, according to research published in the July issue of the U.S. Centers for Disease Control and Prevention’s Emerging Infectious Diseases.

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Sedentary Lifestyle May Up Risk of Renal, Bladder Cancers

THURSDAY, June 15, 2017 (HealthDay News) — New research adds to growing evidence that inactivity may be a significant risk factor for cancer, according to a report published online May 19 in Cancer Epidemiology.

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Risk of HPV-Linked Second Cancers Up After Anal Cancer

THURSDAY, June 15, 2017 (HealthDay News) — Survivors of squamous cell carcinoma of the anus (SCCA) have an elevated risk of human papillomavirus (HPV)-related second primary malignancies (SPMs), according to a study published online June 13 in Cancer.

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Concentrated Broccoli Sprout Extract May Help Fight T2DM

THURSDAY, June 15, 2017 (HealthDay News) — Sulforaphane, found in cruciferous vegetables such as broccoli, may help obese type 2 diabetes patients better regulate dysglycemia, according to a study published in the June 14 issue of Science Translational Medicine.

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Novel Retinal Lesion Seen in Some Ebola Survivors

THURSDAY, June 15, 2017 (HealthDay News) — A small percentage of Ebola virus disease (EVD) survivors have a novel retinal lesion, according to research published in the July issue of the U.S. Centers for Disease Control and Prevention’s Emerging Infectious Diseases.

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Cutaneous Malignancies Can Mimic Seborrheic Keratosis

THURSDAY, June 15, 2017 (HealthDay News) — Of a sample of lesions deemed seborrheic keratoses clinically, 3.1 percent were histologically diagnosed as malignancies, according to research published online June 7 in the Journal of Cutaneous Pathology.

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Good Results for Zone MPC-Based Artificial Pancreas

THURSDAY, June 15, 2017 (HealthDay News) — A zone model predictive control (MPC)-based artificial pancreas (AP) system improves glycemic control in a home-use environment, according to a study published online June 5 in Diabetes Care.

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OpenArray PCR Platform Detects Pathogens in Plasma, Blood

WEDNESDAY, June 14, 2017 (HealthDay News) — The high-throughput OpenArray polymerase chain reaction (PCR) platform can detect and discriminate agents in plasma and blood samples, according to a study published online June 14 in the Journal of Molecular Diagnostics.

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Survey IDs Nail Histopathology Techniques Currently in Use

WEDNESDAY, June 14, 2017 (HealthDay News) — Results of a new survey, published online June 7 in the Journal of Cutaneous Pathology, provide some insight on nail histopathology techniques currently in use.

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Sleep Apnea Linked to Diabetic Retinopathy in Type 2 Diabetes

WEDNESDAY, June 14, 2017 (HealthDay News) — For patients with type 2 diabetes, obstructive sleep apnea (OSA) is associated with sight-threatening diabetic retinopathy (STDR) and with progression to pre-/proliferative DR, according to a study published online June 8 in the American Journal of Respiratory and Critical Care Medicine.

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Prevalence of Antiphospholipid Syndrome Up for Roma SLE

WEDNESDAY, June 14, 2017 (HealthDay News) — The prevalence and risk of antiphospholipid syndrome (APS) is higher for Roma versus Caucasian systemic lupus erythematosus (SLE) patients, according to a study published online June 7 in the International Journal of Rheumatic Diseases.

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Glycation of Hemoglobin Differs by Race

WEDNESDAY, June 14, 2017 (HealthDay News) — Both biological and socioeconomic factors appear to play a role in higher hemoglobin A1c (HbA1c) readings seen in black patients with diabetes, according to research published online June 13 in the Annals of Internal Medicine.

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Case Report: Hyperammonemia to Be Considered in Cirrhosis Setting

TUESDAY, June 13, 2017 (HealthDay News) — Severe hyperammonemia, resulting from ammonia that accumulates in stored blood products, should be considered in the setting of cirrhosis, according to a case report published online June 13 in the Annals of Internal Medicine.

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Idiopathic Pulmonary Fibrosis Algorithm Performs Poorly

TUESDAY, June 13, 2017 (HealthDay News) — The traditional idiopathic pulmonary fibrosis (IPF) algorithm performs poorly, with positive predictive value of 42.2 percent and sensitivity of 55.6 percent, according to a study published in the June 1 issue of the Annals of the American Thoracic Society.

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Cases of Legionnaires’ Disease Reported in NYC, Las Vegas

TUESDAY, June 13, 2017 (HealthDay News) — Cases of Legionnaires’ disease in New York City and Las Vegas are being investigated by health officials.

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Sodium Intake Not Linked to Multiple Sclerosis Progression

TUESDAY, June 13, 2017 (HealthDay News) — There is no association between average 24-hour urine sodium levels and conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (MS), according to a study published online May 26 in the Annals of Neurology.

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Medical Students Lacking Proficiency in BP Measurements

MONDAY, June 12, 2017 (HealthDay News) — Medical students frequently do not achieve mastery of the skills necessary for accurate measurement of blood pressure (BP), according to a study published online April 28 in the Journal of Clinical Hypertension.

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Reduced Corneal Nerve Fiber Density in Patients With HIV

MONDAY, June 12, 2017 (HealthDay News) — Patients with HIV and HIV-associated sensory neuropathy (HIV-SN) have reduced corneal nerve fiber density, which can be identified using in vivo corneal confocal microscopy (IVCCM), according to a study published online June 8 in JAMA Ophthalmology.

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New Bill With Tort Reforms Will Protect Iowa Physicians

FRIDAY, June 9, 2017 (HealthDay News) — A new bill with tort reforms to protect Iowa physicians will take effect July 1, according to a report published by the American Medical Association (AMA).

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Sitagliptin Stimulates Distal Tubular Natriuresis in T2DM

FRIDAY, June 9, 2017 (HealthDay News) — For patients with type 2 diabetes, the dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin stimulates distal tubular natriuresis, according to a study published online May 26 in Diabetes Care.

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Global Climate Change Could Cause Rise in Airway Irritation

FRIDAY, June 9, 2017 (HealthDay News) — Climate change may increase people’s exposure to an outdoor fungus that can damage airway cells, leading to a rise in asthma and allergy symptoms, according to a study published online recently in the American Journal of Physiology-Cell Physiology.

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Low-Fat Dairy Intake May Up Risk of Parkinson’s Disease

FRIDAY, June 9, 2017 (HealthDay News) — Consumption of low-fat dairy foods is linked with a slight increase in the risk of developing Parkinson’s disease, according to a study published online June 8 in Neurology.

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CDC: ~5 Percent of Pregnancies With Zika Result in Birth Defects

FRIDAY, June 9, 2017 (HealthDay News) — About one in 20 women in the U.S. territories who were infected with Zika during pregnancy had babies with possible Zika-associated birth defects, according to research published in the June 8 early-release issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report.

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Lithium’s Risk to Fetus May Be Lower Than Previously Thought

THURSDAY, June 8, 2017 (HealthDay News) — Lithium is linked to an increased risk of heart malformations in infants born to women taking the drug during pregnancy, but the risk is smaller than once believed, according to research published in the June 8 issue of the New England Journal of Medicine.

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U.S. Leads in Income-Based Health Care Inequalities

THURSDAY, June 8, 2017 (HealthDay News) — The United States has larger income-related differences in perceptions of health and health care than other middle- and high-income countries, according to a report published in the June issue of Health Affairs.

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FISH Beneficial for Diagnosing Cholangiocarcinoma

THURSDAY, June 8, 2017 (HealthDay News) — Fluorescence in situ hybridization (FISH) is associated with increased sensitivity compared with brush cytology for diagnosing cholangiocarcinoma in indeterminate biliary strictures, according to a study published online May 19 in the Journal of Gastroenterology and Hepatology.

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Drop in Admission for Aspiration Pneumonia From 2002 to 2012

THURSDAY, June 8, 2017 (HealthDay News) — From 2002 to 2012 there was a decrease in the incidence of admission for aspiration pneumonia, according to research published in the June 1 issue of the Annals of the American Thoracic Society.

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Liver Cancer the Fastest-Growing Cause of Cancer Deaths in U.S.

THURSDAY, June 8, 2017 (HealthDay News) — Liver cancer is the fastest-growing cause of cancer deaths in the United States, with substantial disparity in mortality rates for race/ethnicity and state of residence, according to a study published online June 6 in CA: A Cancer Journal for Clinicians.

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SGLT2 Inhibitors Linked to Increased Risk of Ketoacidosis

THURSDAY, June 8, 2017 (HealthDay News) — Sodium-glucose cotransporter 2 (SGLT2) inhibitors appear to increase the risk of diabetic ketoacidosis in patients with type 2 diabetes, according to a research letter published in the June 8 issue of the New England Journal of Medicine.

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Certain Cancer Diagnoses Up in High-Income Counties in U.S.

THURSDAY, June 8, 2017 (HealthDay News) — Americans living in high-income areas are more likely to be diagnosed with some types of cancer than people living in low-income areas, according to a perspective piece published in the June 8 issue of the New England Journal of Medicine.

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CDC: Legionella Present in Hospital, Nursing Home Plumbing

WEDNESDAY, June 7, 2017 (HealthDay News) — Legionella has been found in the water systems of hospitals, nursing homes and long-term care facilities, putting the most vulnerable patients at risk, U.S. health officials said Tuesday.

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Next-Generation Metagenomic Sequencing IDs Novel RNA Virus

WEDNESDAY, June 7, 2017 (HealthDay News) — Next-generation metagenomic sequencing (NGMS) can detect new viral infections, including a novel RNA virus, human hepegivirus-1 (HHpgV-1), according to a study published online June 6 in the Annals of Internal Medicine.

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Venlafaxine Use Linked to Bone Turnover Markers in Older Adults

TUESDAY, June 6, 2017 (HealthDay News) — Depression treatment with venlafaxine is associated with increased levels of the bone resorption marker C-terminal cross-linking telopeptide of type 1 collagen (CTX), as well as decreased levels of the bone formation marker procollagen type 1 N-propeptide (P1NP), according to a study published online May 26 in the Journal of the American Geriatrics Society.

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CDC: 14 in California Poisoned by Amanita phalloides Mushrooms

MONDAY, June 5, 2017 (HealthDay News) — A bumper crop of Amanita phalloides (“death cap”) mushrooms in northern California is likely to blame for the poisonings of 14 people in December, according to research published in the June 2 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report.

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Hypothalamic Lin28a Shows Role in Glucose Homeostasis

MONDAY, June 5, 2017 (HealthDay News) — An experimental study supports a TANK-binding kinase 1 (TBK-1)-dependent role for Lin28a in the hypothalamic ventromedial nucleus in glucose homeostasis. The study was published online May 26 in Diabetes.

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Mutations in SULT2B1 Tied to Ichthyosis in Humans

MONDAY, June 5, 2017 (HealthDay News) — Scientists have discovered another gene mutation behind certain cases of autosomal-recessive congenital ichthyosis (ARCI), according to a report published in the June 1 issue of the American Journal of Human Genetics.

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Court Ruling Potentially Threatens Physicians’ Immunity

FRIDAY, June 2, 2017 (HealthDay News) — A court ruling allowing a civil rights lawsuit against a medical examiner may have serious consequences for physicians in public service, according to a report published by the American Medical Association.

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Comorbid Celiac Disease Common Among Youth With T1DM

FRIDAY, June 2, 2017 (HealthDay News) — Children with type 1 diabetes often have comorbid celiac disease (CD), according to a study published online May 25 in Diabetes Care.

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Cool Water Works As Well As Hot for Ridding Hands of Germs

FRIDAY, June 2, 2017 (HealthDay News) — For effective hand hygiene, water temperature matters less than time, according to a study published in the June issue of the Journal of Food Protection.

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MTHFR A1298C Polymorphism Not Linked to MTX Outcomes in RA

FRIDAY, June 2, 2017 (HealthDay News) — The methylene tetrahydrofolate reductase (MTHFR) gene A1298C polymorphism does not appear to be related to methotrexate (MTX) efficacy or toxicity in patients with rheumatoid arthritis (RA), according to a meta-analysis published online May 25 in the International Journal of Rheumatic Diseases.

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PERFI Feasible for In Vivo Imaging of Nonmelanoma Skin Cancer

FRIDAY, June 2, 2017 (HealthDay News) — Polarization-enhanced reflectance and fluorescence imaging (PERFI) is feasible for in vivo intraoperative imaging of nonmelanoma skin cancer (NMSC), according to a study published online May 25 in Lasers in Surgery and Medicine.

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Drug-Resistant Bacteria Seen in Many Nursing Home Residents

THURSDAY, June 1, 2017 (HealthDay News) — Multidrug-resistant gram-negative bacteria (MDR-GNB), such as Escherichia coli, can be found in more than one-quarter of nursing-home residents, according to a study published in the May 1 issue of the American Journal of Infection Control.

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Low Albumin Predicts Mortality in Renal Replacement Therapy

THURSDAY, June 1, 2017 (HealthDay News) — Low albumin levels at the start of renal replacement therapy are independently associated with mortality during one-year follow-up, according to a study published online May 23 in the Journal of Renal Care.

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MicroRNA Biomarker Signature Identified for Allergic Asthma

THURSDAY, June 1, 2017 (HealthDay News) — Certain plasma microRNAs (miRNAs) are differentially regulated in allergic asthma and correlate with clinical characteristics, according to an experimental study published online May 17 in Allergy.

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Risk of Conversion to Multiple Sclerosis Down With Minocycline

THURSDAY, June 1, 2017 (HealthDay News) — For patients with a first demyelinating event (clinically isolated syndrome), treatment with minocycline is associated with reduced risk of conversion to multiple sclerosis over six months, according to a study published in the June 1 issue of the New England Journal of Medicine.

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