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Kaposi’s Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen: Replicating and Shielding Viral DNA during Viral Persistence.

Kaposi’s Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen: Replicating and Shielding Viral DNA during Viral Persistence.
Author Information (click to view)

Weidner-Glunde M, Mariggiò G, Schulz TF,


Weidner-Glunde M, Mariggiò G, Schulz TF, (click to view)

Weidner-Glunde M, Mariggiò G, Schulz TF,

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Journal of virology 2017 06 2691(14) pii 10.1128/JVI.01083-16

Abstract

Kaposi’s sarcoma herpesvirus (KSHV) establishes lifelong latency. The viral latency-associated nuclear antigen (LANA) promotes viral persistence by tethering the viral genome to cellular chromosomes and by participating in latent DNA replication. Recently, the structure of the LANA C-terminal DNA binding domain was solved and new cytoplasmic variants of LANA were discovered. We discuss how these findings contribute to our current view of LANA structure and assembly and of its role during viral persistence.

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