Chronic lymphocytic leukemia (CLL) is a low-grade B-lineage lymphoid cancer. However, it may be more diverse than formerly believed. While a lot of cases do not need any form of treatment due to an indolent course, there are other cases where patients ended up becoming symptomatic or have developed hints of rapid advancement of the disease. Treatment of CLL is focused on minimizing the symptoms since the disease usually happens to be noncurative. Determining which patients could have a more aggressive course of the disease at initial diagnosis may be aided by some risk features. The rate of molecular complete remissions had risen owing to up-to-date CLL treatment regimens that included monoclonal antibodies and purine nucleoside analogs. This could in turn improve the rate of survival as well. The possibly curative modality became more widely accessible due to the reduced-intensity allogeneic transplant conditioning regimens. There are huge dangers for infectious complications posed by all of these treatments which ought to be considered cautiously alongside the risks posed by the disease itself. Hence, a proposed treatment algorithm based on these risks is also talked about in this study.