Approximately 2.8 million nonfatal workplace illnesses and injuries were reported in the United States in 2018 (1). Current surveillance methods might underestimate the prevalence of occupational injuries and illnesses (2,3). One way to obtain more information on occupational morbidity is to assess workers’ perceptions about whether they have ever experienced health problems related to work (4). Occupational exposures might directly cause, contribute to, exacerbate, or predispose workers to various health problems (work-related health problems). CDC’s National Institute for Occupational Safety and Health estimated the lifetime prevalence of self-reported, work-related health problems for the currently employed population overall and stratified by various demographic and job characteristics using data from the 2018 version of the SummerStyles survey. Overall, 35.1% of employed respondents had ever experienced a work-related health problem (95% confidence interval [CI] = 33.0%-37.3%). The most commonly reported work-related health problem was back pain (19.4%, 95% CI = 17.6%-21.2%). Among industries, construction (48.6%, 95% CI = 36.54%-60.58%) had the highest prevalence of any work-related health problems. Workplace injury and illness prevention programs are needed to reduce the prevalence of work-related health problems, especially in higher-risk industries.