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Limited HIV-1 Reactivation in Resting CD4(+) T cells from Aviremic Patients under Protease Inhibitors.

Limited HIV-1 Reactivation in Resting CD4(+) T cells from Aviremic Patients under Protease Inhibitors.
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Kumar A, Abbas W, Bouchat S, Gatot JS, Pasquereau S, Kabeya K, Clumeck N, De Wit S, Van Lint C, Herbein G,


Kumar A, Abbas W, Bouchat S, Gatot JS, Pasquereau S, Kabeya K, Clumeck N, De Wit S, Van Lint C, Herbein G, (click to view)

Kumar A, Abbas W, Bouchat S, Gatot JS, Pasquereau S, Kabeya K, Clumeck N, De Wit S, Van Lint C, Herbein G,

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Scientific reports 2016 12 066() 38313 doi 10.1038/srep38313

Abstract

A latent viral reservoir that resides in resting CD4(+) T cells represents a major barrier for eradication of HIV infection. We test here the impact of HIV protease inhibitor (PI) based combination anti-retroviral therapy (cART) over nonnucleoside reverse transcriptase inhibitor (NNRTI)-based cART on HIV-1 reactivation and integration in resting CD4(+) T cells. This is a prospective cohort study of patients with chronic HIV-1 infection treated with conventional cART with an undetectable viremia. We performed a seven-year study of 47 patients with chronic HIV-infection treated with cART regimens and with undetectable plasma HIV-1 RNA levels for at least 1 year. Of these 47 patients treated with cART, 24 were treated with a PI-based regimen and 23 with a NNRTI-based regimen as their most recent treatment for more than one year. We evaluated the HIV-1 reservoir using reactivation assay and integrated HIV-1 DNA, respectively, in resting CD4(+) T cells. Resting CD4(+) T cells isolated from PI-treated patients compared to NNRTI-treated patients showed a limited HIV-1 reactivation upon T-cell stimulation (p = 0·024) and a lower level of HIV-1 integration (p = 0·024). Our study indicates that PI-based cART could be more efficient than NNRTI-based cART for limiting HIV-1 reactivation in aviremic chronically infected patients.

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