This study aimed to assess the association between glucose concentrations and clinical outcomes in patients who underwent endovascular treatment (EVT). From the MR CLEAN Registry, adult patients with a large vessel occlusion of the anterior circulation who underwent endovascular treatment with available admission glucose levels were selected. The association between admission glucose modified Rankin Scale score at 90 day was assessed, along with successful reperfusion rates, and symptomatic intracranial hemorrhage. Hyperglycemia was defined as admission glucose greater than or equal to 7.8 mmol/L.

Of the 3637 patients in the MR CLEAN Registry, 2908 were included. The median admission glucose concentration was at 6.8 mmol/L and about 30% of the participants had hyperglycemia. High-serum glucose on admission was associated with increased mortality (40% vs. 23%), worse functional outcomes (median modified Rankin Scale score 4 vs. 3), and an increased risk of symptomatic intracranial hemorrhage (9% vs. 5%) compared with non hyperglycemic patients.

In conclusion, high glucose was not found to be associated with the rate of successful reperfusion. Furthermore, successful reperfusion does not modify the association between glucose and functional outcome. Increased admission glucose is associated with poor functional outcomes and an increased risk of symptomatic intracranial hemorrhage after EVT.

Ref: https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.029944

Author