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Liver Transplantation: the Role of Metabolic Syndrome.

Liver Transplantation: the Role of Metabolic Syndrome.
Author Information (click to view)

Davis BC, Shadab Siddiqui M,


Davis BC, Shadab Siddiqui M, (click to view)

Davis BC, Shadab Siddiqui M,

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Current treatment options in gastroenterology 2017 04 21() doi 10.1007/s11938-017-0135-1
Abstract
OPINION STATEMENT
The long-term survival in liver transplant recipients (LTRs) is currently at an historical high level stemming from improvement in perioperative care, infection control, and immunosuppression medications. However, compared to the general population, LTRs have decreased survival. Metabolic diseases like hypertension, dyslipidemia, type 2 diabetes, and obesity are key determinants of long-term mortality in LTRs. The incidence and prevalence of these metabolic comorbidities is considerably higher in LTRs and likely results from a combination of factors including exposure to chronic immunosuppression, weight gain, and recurrence of chronic liver disease after liver transplantation (LT). Although there is currently little guidance in managing these metabolic conditions post-LT, recommendations are often extrapolated from non-transplant cohorts. In the current review, we explore the relationship between metabolic syndrome and its comorbidities in LTRs.

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