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LncRNA SPRY4-IT was concerned with the poor prognosis and contributed to the progression of thyroid cancer.

LncRNA SPRY4-IT was concerned with the poor prognosis and contributed to the progression of thyroid cancer.
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Zhou H, Sun Z, Li S, Wang X, Zhou X,


Zhou H, Sun Z, Li S, Wang X, Zhou X, (click to view)

Zhou H, Sun Z, Li S, Wang X, Zhou X,

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Cancer gene therapy 2017 12 12() doi 10.1038/s41417-017-0003-0

Abstract

Long non-coding RNAs (lncRNAs) have been demonstrated to be critical regulators in tumorigenesis. LncRNA SPRY4-IT1 has been identified as critical regulator for hepatocellular carcinoma and ovarian cancer. However, the potential role and clinical value of SPRY4-IT1 in human thyroid cancer (TC) still remain unclear and need to be uncovered. Our current study was aimed to ascertain the biological role of expression of SPRY4-IT1 in TC tissues and cells. Our findings revealed that the level of SPRY4-IT1 was significantly upregulated in TC tissues and cell lines, which was correlated with poor prognosis. And cellular experiments exhibited that silenced SPRY4-IT1 inhibited the proliferative and migratory abilities of TC cells. Mechanism assays noted that silenced SPRY4-IT1 could increase the levels of transforming growth factor-β1 (TGF-β1) and p-Smad2/3 and function mediated by si-SPRY4-IT1 could be rescued by the interference of TGF-β1. Generally speaking, these findings elucidated that SPRY4-IT1 might become a novel prognostic factor in the clinical behaviors of TC patients and participated in the progression of TC through targeting TGF-β/Smad signaling pathway.

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