This scanning electron microscopic (SEM) image shows the presence of numerous human immunodeficiency virus-1 (HIV-1) virions (spherical in appearance) budding from a cultured human lymphocytes in this 1989 image obtained from Centers for Disease Control and Prevention (CDC) in Atlanta, Georgia, U.S. on March 5, 2019. Courtesy C. Goldsmith, P. Feorino, E. L. Palmer, W. R. McManus/CDC/Handout via REUTERS