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Long non-coding RNAs involved in autophagy regulation.

Long non-coding RNAs involved in autophagy regulation.
Author Information (click to view)

Yang L, Wang H, Shen Q, Feng L, Jin H,


Yang L, Wang H, Shen Q, Feng L, Jin H, (click to view)

Yang L, Wang H, Shen Q, Feng L, Jin H,

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Cell death & disease 2017 10 058(10) e3073 doi 10.1038/cddis.2017.464
Abstract

Autophagy degrades non-functioning or damaged proteins and organelles to maintain cellular homeostasis in a physiological or pathological context. Autophagy can be protective or detrimental, depending on its activation status and other conditions. Therefore, autophagy has a crucial role in a myriad of pathophysiological processes. From the perspective of autophagy-related (ATG) genes, the molecular dissection of autophagy process and the regulation of its level have been largely unraveled. However, the discovery of long non-coding RNAs (lncRNAs) provides a new paradigm of gene regulation in almost all important biological processes, including autophagy. In this review, we highlight recent advances in autophagy-associated lncRNAs and their specific autophagic targets, as well as their relevance to human diseases such as cancer, cardiovascular disease, diabetes and cerebral ischemic stroke.

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