For a study, researchers wanted to investigate the relationship between hypertensive diseases of pregnancy and unfavorable postpartum outcomes, such as chronic kidney disease and serious adverse cardiovascular events (cerebrovascular accident, coronary artery disease, or death). From 2004 through 2015, population-based cohort research was undertaken on women with hypertensive disorders of pregnancy. The International Classification of Diseases, Ninth Revision, Clinical Modification codes were used to identify hypertensive diseases of pregnancy. From 2006 through 2013, the research cohort consisted of women aged 20–40 years diagnosed with hypertensive disorders during pregnancy. The comparison group consisted of four randomly chosen women who did not have hypertension disorders during pregnancy. It was matched for age and index date for each woman who had hypertensive pregnancy disorders. All of the women were tracked from when they joined the cohort until they acquired chronic renal disease or had a severe adverse cardiovascular event, or until the end of 2015, whichever came first. The risk of chronic renal disease and significant adverse cardiovascular events was estimated using a Cox proportional hazard model.

Researchers found 29,852 women with hypertension disorders of pregnancy and 119,408 matched women who did not have hypertensive disorders of pregnancy and met the inclusion criteria. The crude hazard ratios (HRs) for chronic renal disease and major adverse cardiovascular events were 5.22 (95% CI 4.67–5.83) and 2.26 (95% CI 1.99–2.57), respectively. After controlling for relevant confounders, hypertensive disorders of pregnancy were linked to an increased risk of chronic renal disease (adjusted HR, 4.26; 95% CI 3.80–4.78) and major adverse cardiovascular events (adjusted HR, 2.15; 95% CI 1.89–2.45).

According to the research, women with hypertension disorders of pregnancy are more likely to develop chronic renal disease. They have more significant adverse cardiovascular events than women who do not have hypertensive disorders of pregnancy. More research is needed to determine these connections’ nature and enhance public health interventions.

Reference:journals.lww.com/greenjournal/Abstract/2021/02000/Long_term_Clinical_Outcome_of_Major_Adverse.14.aspx