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Lower Rate of Adverse Events With Outpatient Treatment of PE

Lower Rate of Adverse Events With Outpatient Treatment of PE
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MONDAY, Feb. 6, 2017 (HealthDay News) — For patients with hemodynamically stable pulmonary embolism (PE), outpatient management is associated with a lower rate of adverse events, according to research published online Jan. 20 in the Journal of Thrombosis and Haemostasis.

Pierre-Marie Roy, M.D., Ph.D., from Université d’Angers in France, and colleagues conducted a retrospective cohort propensity score analysis to determine the net clinical benefit of hospitalization versus outpatient management of normotensive patients with acute PE. A total of 1,081 hemodynamically stable PE patients were included in the matched cohort: 576 were treated as inpatients and 505 as outpatients.

The researchers found that the 14-day rate of adverse events was 13.0 and 3.3 percent for inpatients and outpatients, respectively (adjusted odds ratio, 5.07). For inpatients and outpatients, the three-month adverse event rate was 21.7 and 6.9 percent, respectively (odds ratio, 4.90). The 14-day rate of adverse events was 16.5 and 4.5 percent in the high-risk subgroup for hospitalized patients and outpatients, respectively (odds ratio, 4.16).

“Outpatient treatment of hemodynamically stable PE patients seems associated with a lower rate of adverse events than hospitalization and, if confirmed, may be considered as first-line management in patients not requiring specific in-hospital care, regardless of their initial risk stratification, if proper outpatient care can be provided,” the authors write.

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