For a study, researchers examined the impact of self-reported chronic obstructive pulmonary disease, coronary artery disease, stroke, and diabetes mellitus on diagnostic complications in lung cancer screening evaluation using Prostate, Lung, Colorectal, and Ovarian data Cancer Screening Trial. In the analysis, investigators included participants from the standard care and intervention (annual chest x-ray) arm of the lung cancer screening trial who had undergone an invasive procedure and were at least 55 years old and 20 pack-year smokers. They utilized multivariate logistic regression to examine the relationship between comorbidity and procedure complication. The incidence of serious or moderate problems was the primary outcome measure. Older age (OR=1.03 per year, P=.001), coronary artery disease history (OR=1.40, P=.03), diabetes mellitus history (OR=0.41, P<.001), smoking status (OR=1.46, P≤.001), a surgical biopsy (OR=7.39, P<.001), needle biopsy (OR=1.94, P<.001), and other invasive technique (OR=1.58,  P<.001). Study group found no association between complications and history of stroke or chronic obstructive pulmonary disease (OR=0.84, P=.53 or chronic obstructive pulmonary disease (OR = 1.27, P=.06). Individual risk factors and high-risk consequences data should be included in diagnostic algorithms to maximize clinical benefit and limit the damage. Further investigation and validation of the identified risk factors were required.

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