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Management of Preinvasive Lesions.

Management of Preinvasive Lesions.
Author Information (click to view)

Patrono MG, Corzo C, Iniesta M, Ramirez PT,


Patrono MG, Corzo C, Iniesta M, Ramirez PT, (click to view)

Patrono MG, Corzo C, Iniesta M, Ramirez PT,

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Clinical obstetrics and gynecology 2017 09 27() doi 10.1097/GRF.0000000000000316
Abstract

Serous tubal intraepithelial carcinoma is considered the precursor lesion of high-grade serous carcinoma, and found in both low-risk and high-risk populations. Isolated serous tubal intraepithelial carcinomas in patients with BRCA1/2 mutations are detected in ∼2% of patients undergoing risk-reducing bilateral salpingo-oophorectomy and even with removal of the tubes and ovaries the rate of developing primary peritoneal carcinoma following remains up to 7.5%. Postoperative recommendations after finding incidental STICs remain unclear and surgical staging, adjuvant chemotherapy, or observation have been proposed. Discovery of STIC should prompt consideration of hereditary cancer program referral for BRCA1/2 mutation screening.

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