This study aimed to investigate the status and contribution of filaggrin protein, eosinophil MBP and total IgE in pediatric patients with AD, AR, and BA.
Sera from 395 pediatric patients were taken who were of AD, AR, or BA with varying levels of disease activity according to the disease activity index, and 410 age-matched non-atopic healthy controls were evaluated for serum levels of atopic markers, including filaggrin, eosinophil MBP, and IgE.
Filaggrin levels were remarkably high in pediatric patients with AD, followed by BA and AR, whereas its levels were low in non-atopic pediatric controls. Eosinophil MBP levels were significantly high as compared with their respective controls, but their levels were highest in AR patients, followed by AD and BA. An increased number of subjects werepositive for filaggrin protein, eosinophil MBP or total IgE but also their levels were statistically significantly higher among those atopic patients whose disease activity scores were higher as compared with atopic patients with lower disease activity scores.
The study concluded that there is a strong role of filaggrin protein, eosinophil MBP and IgE in the onset of allergic reactions in pediatric patients with AD, AR, and BA.
Reference: https://clinicalmolecularallergy.biomedcentral.com/articles/10.1186/s12948-018-0102-y
